Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.31 |
| ▸ | CETP | P11597 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7129152 | 0.93 | GCGR (0.38) | GCGRLMNA | |
| SCHEMBL6381544 | 0.93 | GCGR (0.35) | GCGRLMNA | |
| SCHEMBL7129129 | 0.93 | GCGR (0.35) | GCGRLMNA | |
| SCHEMBL7126937 | 0.88 | GCGR (0.33) | GCGR | |
| SCHEMBL7120050 | 0.85 | GCGR (0.36) | GCGRCETP | |
| SCHEMBL6444187 | 0.83 | — | — | |
| SCHEMBL7121156 | 0.79 | CETP (0.42) | GCGRCETP | |
| SCHEMBL7121163 | 0.78 | CETP (0.36) | CETP | |
| SCHEMBL6375081 | 0.78 | CETP (0.48) | CETP | |
| SCHEMBL6424437 | 0.77 | CETP (0.36) | CETP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6586613-B1 | Compounds such as 5-(tert-butyldimethylsiloxy)-7,7-dimethyl -4(4-fluorophenyl)-3-(hydroxy-(4-trifluorophenyl)-methyl)-2-isopropyl -5,6,7,8-tetrahydronaphthalene, used as antagonists for cholesteryl ester transferase protein; hyperlipemia | BAYER AKTIENGELLSCHAFT (DE) | 2003-07-01 | — | — | US | disclosed |