Known targets — ChEMBL curated mechanism
KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2
The experimentally established mechanism targets of Pimagedine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA5A | P35218 | 1/20 | 0.44 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | THPO | P40225 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pimagedine SCHEMBL27817337 | 0.97 | CA5A (0.47) | CA5ACA5BCYP1A2TSHRNFKB1 | |
| Pimagedine SCHEMBL239259 | 0.97 | — | — | |
| Pimagedine SCHEMBL4539956 | 0.97 | CA5A (0.47) | CA5ACA5BCYP1A2TSHRNFKB1 | |
| Pimagedine SCHEMBL11442596 | 0.94 | CA5A (0.44) | CA5ACA5BCYP1A2TSHRNFKB1 | |
| Pimagedine SCHEMBL3171820 | 0.94 | CA5A (0.44) | CA5ACA5BCYP1A2TSHRNFKB1 | |
| Pimagedine SCHEMBL2706225 | 0.86 | CYP1A2 (0.35) | CA5ACA5BCYP1A2TSHRNFKB1 | |
| Guanidine SCHEMBL11252247 | 0.85 | CA5A (0.61) | CA5ACA5B | |
| Guanidine SCHEMBL17844261 | 0.85 | CA5A (0.61) | CA5ACA5B | |
| Guanidine SCHEMBL6384671 | 0.85 | CA5A (0.61) | CA5ACA5B | |
| Guanidine SCHEMBL742686 | 0.85 | CA5A (0.61) | CA5ACA5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6518340-B1 | Flame retardant polycarbonate resin compositions and articles with guanidine salts having high transparency | GENERAL ELECTRIC COMPANY | 2003-02-11 | — | — | US | claimed |