Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARA | P10276 | 4/20 | 0.61 |
| ▸ | RARB | P10826 | 4/20 | 0.61 |
| ▸ | RARG | P13631 | 4/20 | 0.61 |
| ▸ | RXRA | P19793 | 13/20 | 0.60 |
| ▸ | HNF4A | P41235 | 3/20 | 0.56 |
| ▸ | PPARG | P37231 | 1/20 | 0.52 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.52 |
| ▸ | RXRB | P28702 | 1/20 | 0.48 |
| ▸ | RXRG | P48443 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7124980 | 1.00 | RARA (0.61) | RARARARBRARGRXRAHNF4A | |
| SCHEMBL6915189 | 0.99 | RARA (0.60) | RARARARBRARGRXRAHNF4A | |
| SCHEMBL6915866 | 0.98 | RARA (0.64) | RARARARBRARGRXRAHNF4A | |
| SCHEMBL7207880 | 0.94 | RARB (0.64) | RARARARBRARGRXRAHNF4A | |
| SCHEMBL7207884 | 0.94 | RARB (0.64) | RARARARBRARGRXRAHNF4A | |
| SCHEMBL6915722 | 0.89 | RARB (0.67) | RARARARBRARGRXRAHNF4A | |
| SCHEMBL6910086 | 0.87 | RARA (0.50) | RARARARBRARGRXRAHNF4A | |
| SCHEMBL7213506 | 0.85 | RARA (0.44) | RARARARBRARGRXRAHNF4A | |
| SCHEMBL7207780 | 0.85 | RARA (0.48) | RARARARBRARGRXRAHNF4A | |
| SCHEMBL7207067 | 0.84 | RARB (0.63) | RARARARBRARGRXRAHNF4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6610877-B1 | Treating photo and/or age damaged skin | HOFFMAN-LA ROCHE INC. | 2003-08-26 | — | — | US | claimed |
| EP-0641759-B1 | Use of aromatic carboxylic derivatives for the preparation of drugs | HOFFMANN LA ROCHE (CH) | 1998-12-09 | — | — | EP | claimed |
| US-6610877-B1 | Treating photo and/or age damaged skin | HOFFMAN-LA ROCHE INC. | 2003-08-26 | — | — | US | disclosed |
| EP-0817625-B1 | COMPOSITIONS FOR TREATMENT OF PHOTODAMAGED SKIN COMPRISING AN RAR-ALPHA ANTAGONIST AND A MULTI-SELECTIVE RETINOID | HOFFMANN LA ROCHE (CH) | 2003-05-21 | — | — | EP | disclosed |
| EP-0817625-A2 | COMPOSITIONS FOR TREATMENT OF PHOTODAMAGED SKIN COMPRISING AN RAR-ALPHA ANTAGONIST AND A MULTI-SELECTIVE RETINOID | F. HOFFMANN-LA ROCHE AG (CH) | 1998-01-14 | — | — | EP | disclosed |
| WO-1996030009-A2 | COMPOSITIONS FOR TREATMENT OF PHOTODAMAGED SKIN COMPRISING AN RAR-ALPHA ANTAGONIST AND A MULTI-SELECTIVE RETINOID | F. HOFFMANN-LA ROCHE AG (CH) | 1996-10-03 | — | — | WO | disclosed |