Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Levmetamfetamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.78 |
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.78 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.78 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | GMNN | O75496 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methamphetamine SCHEMBL712603 | 1.00 | SIGMAR1 (0.78) | SIGMAR1TAAR1SLC18A2NPC1RAB9A | |
| Methamphetamine SCHEMBL712605 | 1.00 | SIGMAR1 (0.78) | SIGMAR1TAAR1SLC18A2NPC1RAB9A | |
| Methamphetamine SCHEMBL28548051 | 0.96 | SIGMAR1 (0.78) | SIGMAR1TAAR1SLC18A2NPC1RAB9A | |
| Methamphetamine SCHEMBL27438559 | 0.90 | SIGMAR1 (0.95) | SIGMAR1TAAR1SLC18A2NPC1RAB9A | |
| Methamphetamine SCHEMBL18227057 | 0.88 | SIGMAR1 (0.91) | SIGMAR1TAAR1SLC18A2NPC1RAB9A | |
| Levmetamfetamine SCHEMBL727412 | 0.88 | SIGMAR1 (1.00) | SIGMAR1TAAR1SLC18A2NPC1RAB9A | |
| Methamphetamine SCHEMBL13747483 | 0.88 | SIGMAR1 (1.00) | SIGMAR1TAAR1SLC18A2NPC1RAB9A | |
| Methamphetamine SCHEMBL42615 | 0.88 | SIGMAR1 (1.00) | SIGMAR1TAAR1SLC18A2NPC1RAB9A | |
| Methamphetamine SCHEMBL4781849 | 0.88 | SIGMAR1 (1.00) | SIGMAR1TAAR1SLC18A2NPC1RAB9A | |
| Methamphetamine SCHEMBL20211416 | 0.88 | SIGMAR1 (1.00) | SIGMAR1TAAR1SLC18A2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115956053-A | Unit dose dry powder inhaler | 维克多瑞传送设备有限公司 | 2023-04-11 | — | — | CN | disclosed |
| CN-114728137-A | Dry powder inhaler with compliance monitor | 维克多瑞传送设备有限公司 | 2022-07-08 | — | — | CN | disclosed |
| CN-114630689-A | Inhaler for use with compliance monitor | 维克多瑞传送设备有限公司 | 2022-06-14 | — | — | CN | disclosed |
| CN-114599415-A | Dry powder inhaler with compliance and/or compliance monitor | 维克多瑞传送设备有限公司 | 2022-06-07 | — | — | CN | disclosed |
| US-8317991-B2 | Process for electrokinetic migration through liquid membranes | PEDERSEN-BJERGAARD STIG (NO) | 2012-11-27 | — | — | US | disclosed |
| US-8124420-B2 | Reagent, a kit, and a method for detecting and identifying a wide range of illicit drugs | MISTRAL DETECTION LTD (IL) | 2012-02-28 | — | — | US | disclosed |
| US-20110117664-A1 | Reagent, A Kit, And A Method For Detecting And Identifying A Wide Range Of Illicit Drugs | MISTRAL DETECTION LTD. (IL) | 2011-05-19 | — | — | US | disclosed |
| EP-2200972-A2 | A REAGENT, A KIT, AND A METHOD FOR DETECTING AND IDENTIFYING A WIDE RANGE OF ILLICIT DRUGS | Mistral Detection Ltd. (IL) | 2010-06-30 | — | — | EP | disclosed |
| US-20100072066-A1 | Process for electrokinetic migration through liquid membranes | PEDERSEN-BJERGAARD STIG | 2010-03-25 | — | — | US | disclosed |
| WO-2009027967-A2 | A REAGENT, A KIT, AND A METHOD FOR DETECTING AND IDENTIFYING A WIDE RANGE OF ILLICIT DRUGS | MISTRAL DETECTION LTD. (IL) | 2009-03-05 | — | — | WO | disclosed |
| US-6780871-B2 | Methods and compositions for treating addiction disorders | ALBANY MEDICAL COLLEGE | 2004-08-24 | — | — | US | disclosed |
| WO-2002060425-A1 | METHODS AND COMPOSITIONS FOR TREATING ADDICTION DISORDERS | ALBANY MEDICAL COLLEGE (US) | 2002-08-08 | — | — | WO | disclosed |
| US-20020103109-A1 | Methods and compositions for treating addiction disorders | NIH | 2002-08-01 | — | — | US | disclosed |