Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | MGAM | O43451 | 1/20 | 0.37 |
| ▸ | SI | P14410 | 1/20 | 0.37 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.37 |
| ▸ | SLC27A2 | O14975 | 1/20 | 0.36 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALPL | P05186 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | ALPI | P09923 | 1/20 | 0.35 |
| ▸ | ALPG | P10696 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6429764 | 0.82 | PGR (0.40) | — | |
| SCHEMBL6013826 | 0.75 | PGR (0.37) | BACE1PTP4A3MAOBPTPN1 | |
| SCHEMBL6013828 | 0.75 | PGR (0.37) | BACE1PTP4A3MAOBPTPN1 | |
| SCHEMBL28010057 | 0.64 | TP53 (0.48) | CYP3A4CYP2C19BACE1GAAMGAM | |
| SCHEMBL1223242 | 0.64 | PGR (0.55) | POLBCYP3A4CYP2C19 | |
| SCHEMBL19235307 | 0.64 | IP6K1 (0.49) | CYP3A4CYP2C19MAPTKDM4EALDH1A1 | |
| SCHEMBL14524564 | 0.64 | BACE1 (0.52) | BACE1GAASLC27A2ADAMTS5MAPT | |
| SCHEMBL15426102 | 0.63 | TP53 (0.67) | BACE1GAAMGAMSIMGAM2 | |
| SCHEMBL19410676 | 0.63 | PGR (0.62) | SLC27A2ADAMTS5MAPTKDM4EALDH1A1 | |
| SCHEMBL22904130 | 0.63 | CMA1 (0.45) | POLBCYP3A4CYP2C19GAAMGAM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6583145-B1 | Thio-oxindole derivatives | WYETH | 2003-06-24 | — | — | US | disclosed |