Sugi Predict

Sugi Predict / Compounds / SCHEMBL712803

SCHEMBL712803

SCHEMBL712803

COc1ccccc1-c1cnc2[nH]c(-c3cc(OCc4ccccc4)ccc3OC(C)C)nc2c1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 5/20 0.44
▸ KDM4E B2RXH2 2/20 0.44
▸ PDGFRB P09619 2/20 0.41
▸ PDGFRA P16234 2/20 0.41
▸ MAPK1 P28482 3/20 0.40
▸ PRMT5 O14744 1/20 0.39
▸ STK10 O94804 1/20 0.39
▸ SLK Q9H2G2 1/20 0.39
▸ NPSR1 Q6W5P4 2/20 0.38
▸ POLB P06746 1/20 0.38
▸ FFAR1 O14842 2/20 0.38
▸ PDE4A P27815 1/20 0.37
▸ PDE4B Q07343 1/20 0.37
▸ PDE4C Q08493 1/20 0.37
▸ PDE4D Q08499 1/20 0.37
▸ GRM5 P41594 1/20 0.37
▸ ABL1 P00519 1/20 0.37
▸ ALDH1A1 P00352 1/20 0.37
▸ LMNA P02545 1/20 0.37
▸ ALOX12 P18054 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL709840 0.93 GRIN1 (0.42) MAPTKDM4EPDGFRBPDGFRAMAPK1
SCHEMBL720491 0.93 MAPT (0.46) MAPTKDM4EPDGFRBPDGFRAMAPK1
SCHEMBL710136 0.91 MAPT (0.43) MAPTPDGFRBPDGFRAMAPK1PRMT5
SCHEMBL10206516 0.91 MCL1 (0.41) MAPTKDM4EPDGFRBPDGFRAMAPK1
SCHEMBL713544 0.90 FFAR1 (0.40) PDGFRBPDGFRAPRMT5FFAR1
SCHEMBL712000 0.90 PRMT5 (0.38) MAPTKDM4EPDGFRBPDGFRAMAPK1
SCHEMBL711592 0.89 MCL1 (0.40) MAPTKDM4EPDGFRBPDGFRAMAPK1
SCHEMBL713393 0.88 GRIN1 (0.43) MAPTKDM4EPDGFRBPDGFRAMAPK1
SCHEMBL711145 0.87 SCD (0.42) PDGFRBPDGFRAFFAR1PDE4B
SCHEMBL719831 0.87 MAP4K4 (0.43) MAPTMAPK1PRMT5ALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1940837-B1 IMIDAZOPYRIDINE COMPOUNDS TAKEDA PHARMACEUTICAL (JP) 2012-11-07 — — EP disclosed
US-8124617-B2 Imidazopyridine compounds TAKEDA SAN DIEGO, INC. (US) 2012-02-28 — — US disclosed
US-8124617-B2 Imidazopyridine compounds TAKEDA SAN DIEGO, INC. (US) 2012-02-28 — — US disclosed
US-8124617-B2 Imidazopyridine compounds TAKEDA SAN DIEGO, INC. (US) 2012-02-28 — — US disclosed
US-20100069431-A1 IMIDAZOPYRIDINE COMPOUNDS TAKEDA SAN DIEGO, INC. 2010-03-18 — — US disclosed
US-20100069431-A1 IMIDAZOPYRIDINE COMPOUNDS TAKEDA SAN DIEGO, INC. 2010-03-18 — — US disclosed
US-20100069431-A1 IMIDAZOPYRIDINE COMPOUNDS TAKEDA SAN DIEGO, INC. 2010-03-18 — — US disclosed
EP-1940837-A2 IMIDAZOPYRIDINE COMPOUNDS Takeda Pharmaceutical Company Limited (JP) 2008-07-09 — — EP disclosed
WO-2007028135-A2 IMIDAZOPYRIDINE COMPOUNDS TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2007-03-08 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100069431-A1 IMIDAZOPYRIDINE COMPOUNDS GCK, GCKR, KHK MAPT 3003/4885KDM4E 1923/4885PDGFRB 3099/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.