Sugi Predict

Sugi Predict / Compounds / SCHEMBL710136

SCHEMBL710136

SCHEMBL710136

COc1ccc(-c2cnc3[nH]c(-c4cc(OCc5ccccc5)ccc4OC(C)C)nc3c2)cc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 3/20 0.43
▸ NPSR1 Q6W5P4 2/20 0.43
▸ MAPK1 P28482 2/20 0.43
▸ NOD2 Q9HC29 1/20 0.43
▸ PDGFRB P09619 2/20 0.41
▸ PDGFRA P16234 2/20 0.41
▸ MCL1 Q07820 1/20 0.40
▸ PRMT5 O14744 1/20 0.40
▸ DYRK1A Q13627 1/20 0.39
▸ DYRK1B Q9Y463 1/20 0.39
▸ CYP2E1 P05181 1/20 0.39
▸ CYP3A4 P08684 1/20 0.39
▸ CYP2C8 P10632 1/20 0.39
▸ CYP2D6 P10635 1/20 0.39
▸ CYP2C9 P11712 1/20 0.39
▸ CYP2B6 P20813 1/20 0.39
▸ CYP2C19 P33261 1/20 0.39
▸ PDE4A P27815 1/20 0.38
▸ PDE4B Q07343 1/20 0.38
▸ PDE4C Q08493 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10206516 0.94 MCL1 (0.41) MAPTNPSR1MAPK1PDGFRBPDGFRA
SCHEMBL720489 0.93 MAPT (0.46) MAPTNPSR1MAPK1NOD2PDGFRB
SCHEMBL711592 0.92 MCL1 (0.40) MAPTNPSR1MAPK1PDGFRBPDGFRA
SCHEMBL719831 0.92 MAP4K4 (0.43) MAPTMAPK1MCL1PRMT5C5AR1
SCHEMBL709840 0.91 GRIN1 (0.42) MAPTNPSR1MAPK1NOD2PDGFRB
SCHEMBL712803 0.91 MAPT (0.44) MAPTNPSR1MAPK1NOD2PDGFRB
SCHEMBL713544 0.88 FFAR1 (0.40) PDGFRBPDGFRAMCL1PRMT5KIT
SCHEMBL712000 0.88 PRMT5 (0.38) MAPTMAPK1PDGFRBPDGFRAMCL1
SCHEMBL708886 0.88 GPR34 (0.40) PDGFRBPDGFRAMCL1PDE4BC5AR1
SCHEMBL711177 0.88 PRMT5 (0.42) MAPTMAPK1PDGFRBPDGFRAPRMT5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1940837-B1 IMIDAZOPYRIDINE COMPOUNDS TAKEDA PHARMACEUTICAL (JP) 2012-11-07 — — EP disclosed
US-8124617-B2 Imidazopyridine compounds TAKEDA SAN DIEGO, INC. (US) 2012-02-28 — — US disclosed
US-8124617-B2 Imidazopyridine compounds TAKEDA SAN DIEGO, INC. (US) 2012-02-28 — — US disclosed
US-8124617-B2 Imidazopyridine compounds TAKEDA SAN DIEGO, INC. (US) 2012-02-28 — — US disclosed
US-20100069431-A1 IMIDAZOPYRIDINE COMPOUNDS TAKEDA SAN DIEGO, INC. 2010-03-18 — — US disclosed
US-20100069431-A1 IMIDAZOPYRIDINE COMPOUNDS TAKEDA SAN DIEGO, INC. 2010-03-18 — — US disclosed
US-20100069431-A1 IMIDAZOPYRIDINE COMPOUNDS TAKEDA SAN DIEGO, INC. 2010-03-18 — — US disclosed
EP-1940837-A2 IMIDAZOPYRIDINE COMPOUNDS Takeda Pharmaceutical Company Limited (JP) 2008-07-09 — — EP disclosed
WO-2007028135-A2 IMIDAZOPYRIDINE COMPOUNDS TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2007-03-08 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100069431-A1 IMIDAZOPYRIDINE COMPOUNDS GCK, GCKR, KHK MAPT 3003/4885NPSR1 4489/4885MAPK1 863/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.