Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 5/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.46 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.46 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.46 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7125609 | 0.92 | HTT (0.55) | PDE5AHTTMAPTSMN1; SMN2MEN1 | |
| SCHEMBL7122823 | 0.87 | HTT (0.50) | PDE5AHTTMAPTSMN1; SMN2MEN1 | |
| SCHEMBL5781601 | 0.86 | HTT (0.45) | PDE5AHTTMAPTSMN1; SMN2MEN1 | |
| SCHEMBL5781127 | 0.86 | MAPT (0.48) | PDE5AHTTMAPTSMN1; SMN2MEN1 | |
| SCHEMBL5781706 | 0.85 | HTT (0.48) | PDE5AHTTMAPTSMN1; SMN2MEN1 | |
| SCHEMBL5780791 | 0.85 | HTT (0.48) | PDE5AHTTMAPTSMN1; SMN2MEN1 | |
| SCHEMBL7127406 | 0.84 | MAPT (0.47) | PDE5AHTTMAPTSMN1; SMN2MEN1 | |
| SCHEMBL5116457 | 0.82 | ALDH1A1 (0.47) | HTTMAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL5781621 | 0.82 | PDE5A (0.57) | PDE5AHTTMAPTSMN1; SMN2MEN1 | |
| SCHEMBL5798508 | 0.82 | PDE5A (0.57) | PDE5AHTTMAPTSMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0920431-B1 | THIENOPYRIMIDINES | MERCK PATENT GMBH (DE) | 2003-02-26 | — | — | EP | disclosed |
| US-6110920-A | TREATMENT OF CARDIOVASCULAR DISORDERS AND IMPOTENCY | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-08-29 | — | — | US | disclosed |
| EP-0920431-A1 | THIENOPYRIMIDINES | MERCK PATENT GmbH (DE) | 1999-06-09 | — | — | EP | disclosed |
| WO-1998006722-A1 | THIENOPYRIMIDINES | MERCK PATENT GMBH (DE) | 1998-02-19 | — | — | WO | disclosed |