Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | CA2 | P00918 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | CA4 | P22748 | 1/20 | 0.35 |
| ▸ | TPMT | P51580 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7127616 | 0.83 | HSD17B10 (0.53) | GPR35HSD17B10PTPN1MAPTSMN1; SMN2 | |
| SCHEMBL9170185 | 0.78 | PTPN1 (0.35) | GPR35HSD17B10PTPN1MAPTSMN1; SMN2 | |
| SCHEMBL1515828 | 0.78 | HSD17B10 (0.43) | HSD17B10PTPN1TSHRAPOBEC3AHTT | |
| SCHEMBL2202238 | 0.78 | TDP1 (0.44) | HSD17B10MAPTRAB9ATDP1ALDH1A1 | |
| SCHEMBL29997568 | 0.78 | TDP1 (0.44) | HSD17B10MAPTRAB9ATDP1ALDH1A1 | |
| SCHEMBL8492599 | 0.76 | MAPT (0.52) | HSD17B10MAPTSMN1; SMN2TSHRALDH1A1 | |
| SCHEMBL11815709 | 0.76 | ALDH1A1 (0.37) | ALDH1A1ALOX15 | |
| SCHEMBL21828912 | 0.74 | SMN1; SMN2 (0.47) | MAPTSMN1; SMN2TSHRTDP1ALDH1A1 | |
| SCHEMBL6215179 | 0.73 | HSD17B10 (0.55) | GPR35HSD17B10PTPN1MAPTTSHR | |
| SCHEMBL11521097 | 0.73 | TSHR (0.44) | PTPN1MAPTTSHRAPOBEC3AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-6247891-A | — | — | None | — | — | JP | disclosed |
| EP-0793656-B1 | NOVEL BENZYL PYRIMIDINES | BASILEA PHARMACEUTICA AG (CH) | 2003-03-26 | — | — | EP | disclosed |
| US-5763450-A | BACTERICIDES; TREATMENT OF INFECTIOUS DISEASES | HOFFMANN-LA ROCHE INC. (US) | 1998-06-09 | — | — | US | disclosed |
| EP-0793656-A1 | NOVEL BENZYL PYRIMIDINES | F. HOFFMANN-LA ROCHE AG (CH) | 1997-09-10 | — | — | EP | disclosed |
| WO-1996016046-A2 | NOVEL BENZYL PYRIMIDINES | F. HOFFMANN-LA ROCHE AG (CH) | 1996-05-30 | — | — | WO | disclosed |
| JP-H06247891-A | CYCLOHEXANEDIONE DERIVATIVE AND HERBICIDE | HOKKO CHEM IND CO LTD | 1994-09-06 | — | — | JP | disclosed |