SCHEMBL7128201

SCHEMBL7128201

COc1cc(S(=O)(=O)Nc2ccc(Cl)c(OC3CCN(C)C3)c2)ccc1C(F)(F)F

nearest known ligand 0.67

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
UTS2R Q9UKP6 16/20 0.67
TP53 P04637 1/20 0.45
MAPT P10636 1/20 0.45
MEN1 O00255 2/20 0.45
KMT2A Q03164 2/20 0.45
LMNA P02545 2/20 0.45
ALDH1A1 P00352 1/20 0.45
PKM P14618 1/20 0.45
TSHR P16473 1/20 0.45
NPSR1 Q6W5P4 1/20 0.45
HTT P42858 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7128200 1.00 UTS2R (0.67) UTS2RTP53MAPTMEN1KMT2A
SCHEMBL5835300 0.90 UTS2R (0.75) UTS2RMEN1KMT2ALMNAALDH1A1
SCHEMBL5835295 0.90 UTS2R (0.75) UTS2RMEN1KMT2ALMNAALDH1A1
SCHEMBL5835265 0.89 UTS2R (0.73) UTS2RMAPTMEN1KMT2ALMNA
SCHEMBL5835262 0.89 UTS2R (0.73) UTS2RMAPTMEN1KMT2ALMNA
SCHEMBL5835321 0.89 UTS2R (0.73) UTS2RMAPTMEN1KMT2ALMNA
SCHEMBL5835058 0.86 UTS2R (0.75) UTS2R
SCHEMBL8339355 0.86 UTS2R (0.70) UTS2RMAPTLMNA
SCHEMBL5835064 0.86 UTS2R (0.75) UTS2R
SCHEMBL5835457 0.86 UTS2R (0.67) UTS2RMAPTMEN1KMT2ALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2004043366-A2 SULFONAMIDES SMITHKLINE BEECHAM CORPORATION (US) 2004-05-27 WO disclosed