SCHEMBL8339355

SCHEMBL8339355

COc1ccc(S(=O)(=O)Nc2ccc(C(F)(F)F)c(O[C@@H]3CCN(C)C3)c2)cc1F

nearest known ligand 0.70

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
UTS2R Q9UKP6 16/20 0.70
LMNA P02545 1/20 0.47
ERAP1 Q9NZ08 1/20 0.46
MAPT P10636 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5835300 0.93 UTS2R (0.75) UTS2RLMNAERAP1
SCHEMBL5835295 0.93 UTS2R (0.75) UTS2RLMNAERAP1
SCHEMBL6824191 0.93 UTS2R (0.67) UTS2RERAP1
SCHEMBL6819749 0.93 UTS2R (0.67) UTS2RERAP1
SCHEMBL8339345 0.92 UTS2R (0.66) UTS2RLMNAMAPT
SCHEMBL6817433 0.88 UTS2R (0.68) UTS2R
SCHEMBL5835457 0.87 UTS2R (0.67) UTS2RLMNAMAPT
SCHEMBL5835460 0.87 UTS2R (0.67) UTS2RLMNAMAPT
SCHEMBL6821201 0.87 UTS2R (0.68) UTS2RLMNAERAP1
SCHEMBL6821206 0.87 UTS2R (0.68) UTS2RLMNAERAP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2004043366-A2 SULFONAMIDES SMITHKLINE BEECHAM CORPORATION (US) 2004-05-27 WO disclosed