Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Diethanolamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 1/20 | 0.32 |
| ▸ | HTR1B | P28222 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8980538 | 0.77 | KMT2A (0.50) | MAPK1POLBKDM4EMEN1GAA | |
| Diethanolamine SCHEMBL23363665 | 0.74 | TSHR (0.36) | HTR1DHTR1BMAPK1POLBKDM4E | |
| Diethanolamine SCHEMBL8930798 | 0.74 | TSHR (0.36) | HTR1DHTR1BMAPK1POLBKDM4E | |
| Diethanolamine SCHEMBL5307430 | 0.74 | TSHR (0.36) | HTR1DHTR1BMAPK1POLBKDM4E | |
| Diethanolamine SCHEMBL5843119 | 0.74 | — | — | |
| Diethanolamine SCHEMBL2324 | 0.74 | — | — | |
| Diethanolamine SCHEMBL3738131 | 0.72 | SMN1; SMN2 (0.32) | POLBSMN1; SMN2 | |
| Diethanolamine SCHEMBL7893791 | 0.71 | — | — | |
| Diethanolamine SCHEMBL11593620 | 0.71 | — | — | |
| SCHEMBL10892467 | 0.71 | SMN1; SMN2 (0.39) | MAPK1POLBKDM4ESMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5173341-A | Coating wire with triazine-thiol derivative, drawing wire thorugh bath, polymerizing triazine-thiol | TOKYO ROPE MFG. CO., LTD. (JP) | 1992-12-22 | — | — | US | claimed |
| US-20030143457-A1 | Air-hydrogen cell | HITACHI MAXELL ENERGY, LTD. (JP) | 2003-07-31 | — | — | US | disclosed |
| EP-0470280-B1 | Method for manufacturing polymeric coated steel wires for rubber reinforcement | TOKYO ROPE MFG CO (JP) | 1996-12-11 | — | — | EP | disclosed |
| US-5173341-A | Coating wire with triazine-thiol derivative, drawing wire thorugh bath, polymerizing triazine-thiol | TOKYO ROPE MFG. CO., LTD. (JP) | 1992-12-22 | — | — | US | disclosed |
| EP-0470280-A1 | Method for manufacturing polymeric coated steel wires for rubber reinforcement | TOKYO ROPE MANUFACTURING CO., LTD. (JP) | 1992-02-12 | — | — | EP | disclosed |