Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 16/20 | 0.74 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.51 |
| ▸ | FLT1 | P17948 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL446385 | 0.99 | KDR (0.73) | KDRTDP1L3MBTL1TSHRABCB1 | |
| SCHEMBL429097 | 0.85 | KDR (1.00) | KDRABCB1FLT1 | |
| SCHEMBL429582 | 0.84 | KDR (1.00) | KDRABCB1FLT1 | |
| Hydrochloric Acid SCHEMBL448754 | 0.84 | KDR (0.98) | KDRABCB1FLT1 | |
| Hydrochloric Acid SCHEMBL449654 | 0.84 | KDR (0.98) | KDRABCB1FLT1 | |
| SCHEMBL3151267 | 0.82 | KDR (0.64) | KDR | |
| SCHEMBL7128428 | 0.80 | KDR (0.63) | KDRABCB1FLT1 | |
| SCHEMBL446392 | 0.79 | KDR (0.66) | KDRABCB1FLT1 | |
| Hydrochloric Acid SCHEMBL444751 | 0.79 | KDR (0.62) | KDRABCB1FLT1 | |
| SCHEMBL447047 | 0.78 | KDR (0.73) | KDRFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358184-A1 | SUBSTITUTED ALKYLAMINE DERIVATIVES AND METHODS OF USE | Amgen Inc. (US) | 2003-11-05 | — | — | EP | claimed |
| WO-2002066470-A1 | SUBSTITUTED ALKYLAMINE DERIVATIVES AND METHODS OF USE | AMGEN INC. (US) | 2002-08-29 | — | — | WO | claimed |
| EP-1358184-A1 | SUBSTITUTED ALKYLAMINE DERIVATIVES AND METHODS OF USE | Amgen Inc. (US) | 2003-11-05 | — | — | EP | disclosed |
| WO-2002066470-A1 | SUBSTITUTED ALKYLAMINE DERIVATIVES AND METHODS OF USE | AMGEN INC. (US) | 2002-08-29 | — | — | WO | disclosed |