Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACP1 | P24666 | 1/20 | 0.52 |
| ▸ | TMPRSS4 | Q9NRS4 | 2/20 | 0.47 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | P2RX4 | Q99571 | 2/20 | 0.44 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.44 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.44 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 5/20 | 0.44 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.43 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.42 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.41 |
| ▸ | TEK | Q02763 | 2/20 | 0.41 |
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL449135 | 0.91 | ACP1 (0.60) | ACP1TMPRSS4NOTUMMAPTP2RX4 | |
| SCHEMBL16904552 | 0.88 | MAPT (0.53) | ACP1MAPTNR2E1GPR35P2RX1 | |
| SCHEMBL1992521 | 0.83 | ALDH1A1 (0.55) | ACP1MAPT | |
| SCHEMBL5773763 | 0.79 | MAPT (0.67) | ACP1TMPRSS4MAPTP2RX4P2RX7 | |
| SCHEMBL5448110 | 0.79 | ACP1 (0.60) | ACP1TMPRSS4NOTUMMAPTP2RX4 | |
| SCHEMBL29426986 | 0.78 | TSHR (0.46) | ACP1NOTUMMAPTNR2E1TAS2R14 | |
| SCHEMBL134690 | 0.78 | TSHR (0.46) | ACP1NOTUMMAPTNR2E1TAS2R14 | |
| SCHEMBL11786916 | 0.77 | ACP1 (0.61) | ACP1TMPRSS4NOTUMMAPTP2RX4 | |
| SCHEMBL1925848 | 0.77 | ACP1 (0.61) | ACP1TMPRSS4NOTUMMAPTP2RX4 | |
| SCHEMBL12513693 | 0.76 | MAPT (0.78) | ACP1TMPRSS4NOTUMMAPTP2RX4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358184-A1 | SUBSTITUTED ALKYLAMINE DERIVATIVES AND METHODS OF USE | Amgen Inc. (US) | 2003-11-05 | — | — | EP | disclosed |
| WO-2002066470-A1 | SUBSTITUTED ALKYLAMINE DERIVATIVES AND METHODS OF USE | AMGEN INC. (US) | 2002-08-29 | — | — | WO | disclosed |