Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1B1 | Q16678 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | BRD1 | O95696 | 1/20 | 0.45 |
| ▸ | TAF1 | P21675 | 1/20 | 0.45 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.45 |
| ▸ | CRHBP | P24387 | 1/20 | 0.45 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | ADRA1D | P25100 | 7/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 7/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 7/20 | 0.44 |
| ▸ | PLK1 | P53350 | 2/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7131242 | 0.97 | CYP1B1 (0.47) | CYP1B1MEN1KMT2ARAB9AMAPK1 | |
| SCHEMBL7130585 | 0.93 | BRD1 (0.49) | CYP1B1MEN1KMT2ARAB9AMAPK1 | |
| SCHEMBL7129158 | 0.92 | CYP1B1 (0.45) | CYP1B1MEN1KMT2ARAB9AMAPK1 | |
| SCHEMBL7130468 | 0.90 | BRD1 (0.49) | CYP1B1MEN1KMT2ARAB9AMAPK1 | |
| SCHEMBL7127692 | 0.89 | BRD1 (0.52) | CYP1B1MEN1KMT2ARAB9AMAPK1 | |
| SCHEMBL7130986 | 0.89 | CYP1B1 (0.55) | CYP1B1MEN1KMT2ARAB9AMAPK1 | |
| SCHEMBL7123695 | 0.89 | MEN1 (0.52) | CYP1B1MEN1KMT2ARAB9AMAPK1 | |
| SCHEMBL7129206 | 0.88 | MEN1 (0.61) | CYP1B1MEN1KMT2ARAB9AMAPK1 | |
| SCHEMBL7124526 | 0.88 | CYP1B1 (0.48) | CYP1B1MEN1KMT2ARAB9AMAPK1 | |
| SCHEMBL7129139 | 0.88 | CYP1B1 (0.54) | CYP1B1MEN1KMT2ARAB9AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6667303-B1 | Agonists for serotonin 5-hydroxytryptamine 2C(5HT2C) receptor; 6-(1,4-diazepan-1-yl)benzo(cd)indol-2(1H)-ones, 6-(1,4-diazepan-1-yl)acenaphthylen-1(2H)-ones, and 5-(1,4-diazepan-1-yl)- 2H-naphtho(1,8-cd)isothiazole-1,1-dioxides | WYETH | 2003-12-23 | — | — | US | claimed |