Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 4/20 | 0.85 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | BLM | P54132 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | RGS12 | O14924 | 2/20 | 0.38 |
| ▸ | GMNN | O75496 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7080302 | 0.92 | HMGCR (1.00) | HMGCRNR1I2CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL7137096 | 0.84 | HMGCR (0.83) | HMGCRNR1I2CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL7134494 | 0.82 | HMGCR (0.85) | HMGCRNR1I2CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL10441006 | 0.80 | HMGCR (0.54) | HMGCRNR1I2CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL7519713 | 0.80 | HMGCR (0.54) | HMGCRNR1I2CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL7139090 | 0.76 | HMGCR (0.71) | HMGCRNR1I2CYP1A2CYP2C9GABBR2 | |
| SCHEMBL7141651 | 0.76 | HMGCR (0.71) | HMGCRNR1I2CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL9358094 | 0.75 | HMGCR (0.62) | HMGCRNR1I2CYP1A2CYP2C9ALDH1A1 | |
| SCHEMBL7134489 | 0.75 | HMGCR (0.65) | HMGCRNR1I2CYP1A2CYP3A4LMNA | |
| SCHEMBL7083575 | 0.73 | HMGCR (0.63) | HMGCRNR1I2MEN1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1326618-A2 | USE OF ARYL-SUBSTITUTED 1,1-DIPHOSPHONATES FOR THE TREATMENT OF BONE DISEASES | Ilex Oncology Research S.A. (CH) | 2003-07-16 | — | — | EP | claimed |
| WO-2002011704-A2 | USE OF ARYL-SUBSTITUTED 1,1-DIPHOSPHONATES FOR THE TREATMENT OF BONE DISEASES | SYMPHAR S.A. (CH) | 2002-02-14 | — | — | WO | claimed |
| EP-0845991-B1 | USE OF PHENOL SUBSTITUTED DIPHOSPHONATES AS ANTINEOPLASTIC AGENTS | SYMPHAR SA (CH) | 2002-02-06 | — | — | EP | claimed |
| EP-0845991-A2 | USE OF PHENOL SUBSTITUTED DIPHOSPHONATES AS ANTINEOPLASTIC AGENTS | SYMPHAR S.A. (CH) | 1998-06-10 | — | — | EP | claimed |
| WO-1997004785-A1 | USE OF PHENOL SUBSTITUTED DIPHOSPHONATES AS ANTINEOPLASTIC AGENTS | SYMPHAR S.A. (CH) | 1997-02-13 | — | — | WO | claimed |
| EP-0845991-B1 | USE OF PHENOL SUBSTITUTED DIPHOSPHONATES AS ANTINEOPLASTIC AGENTS | SYMPHAR SA (CH) | 2002-02-06 | — | — | EP | disclosed |
| US-6127350-A | FOR TREATMENT AND PREVENTION OF RAS ONCOGENE DEPENDENT CANCERS AND METASTATIC INVASIONS | SYMPHAR S.A. (SE) | 2000-10-03 | — | — | US | disclosed |