Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 6/20 | 0.63 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.32 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.32 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6942208 | 0.83 | HMGCR (0.63) | HMGCRNR1I2KMT2AMEN1GAA | |
| SCHEMBL9358182 | 0.82 | MEN1 (0.40) | HMGCRNR1I2KMT2AMEN1GAA | |
| SCHEMBL7080094 | 0.81 | HMGCR (0.51) | HMGCRNR1I2KMT2AMEN1GAA | |
| SCHEMBL7083231 | 0.79 | HMGCR (0.49) | HMGCRNR1I2KMT2AMEN1GAA | |
| SCHEMBL6942222 | 0.78 | HMGCR (0.48) | HMGCRNR1I2KMT2AMEN1GAA | |
| SCHEMBL7080149 | 0.78 | HMGCR (0.42) | HMGCR | |
| SCHEMBL7080302 | 0.78 | HMGCR (1.00) | HMGCRNR1I2KMT2AMEN1GAA | |
| SCHEMBL9358094 | 0.77 | HMGCR (0.62) | HMGCRNR1I2ALDH1A1 | |
| SCHEMBL9358736 | 0.77 | HMGCR (0.44) | HMGCRNR1I2KMT2AALDH1A1L3MBTL1 | |
| SCHEMBL7129381 | 0.73 | HMGCR (0.85) | HMGCRNR1I2KMT2AMEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1326618-A2 | USE OF ARYL-SUBSTITUTED 1,1-DIPHOSPHONATES FOR THE TREATMENT OF BONE DISEASES | Ilex Oncology Research S.A. (CH) | 2003-07-16 | — | — | EP | claimed |
| WO-2002011704-A2 | USE OF ARYL-SUBSTITUTED 1,1-DIPHOSPHONATES FOR THE TREATMENT OF BONE DISEASES | SYMPHAR S.A. (CH) | 2002-02-14 | — | — | WO | claimed |
| EP-0418064-B1 | Naphthalene and tetrahydronaphthalene gem-diphosphonate derivatives | SYMPHAR SA (CH) | 1994-12-14 | — | — | EP | claimed |
| US-5204336-A | Anticholestrol agents | SYMPHAR S.A. (CH) | 1993-04-20 | — | — | US | claimed |
| EP-0418064-A2 | Naphthalene and tetrahydronaphthalene gem-diphosphonate derivatives | SYMPHAR S.A. (CH) | 1991-03-20 | — | — | EP | claimed |