Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 12/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.47 |
| ▸ | RET | P07949 | 4/20 | 0.42 |
| ▸ | PLK4 | O00444 | 1/20 | 0.42 |
| ▸ | GAK | O14976 | 1/20 | 0.42 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.42 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.42 |
| ▸ | ERN1 | O75460 | 1/20 | 0.42 |
| ▸ | STK10 | O94804 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | FYN | P06241 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
| ▸ | YES1 | P07947 | 1/20 | 0.42 |
| ▸ | LYN | P07948 | 1/20 | 0.42 |
| ▸ | MET | P08581 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7128004 | 0.86 | KDR (0.41) | KDRPDGFRBRETPLK4GAK | |
| SCHEMBL5015572 | 0.85 | KDR (0.53) | KDRPDGFRBRETPLK4GAK | |
| SCHEMBL5017303 | 0.78 | KDR (0.49) | KDRPDGFRBRETPLK4GAK | |
| SCHEMBL5025614 | 0.78 | KDR (0.54) | KDRPDGFRBRETPLK4GAK | |
| SCHEMBL5025618 | 0.78 | KDR (0.54) | KDRPDGFRBRETPLK4GAK | |
| SCHEMBL5015549 | 0.77 | KDR (0.51) | KDRPDGFRBRETPLK4GAK | |
| SCHEMBL13998322 | 0.77 | KDR (0.54) | KDRPDGFRBRETPLK4GAK | |
| SCHEMBL5025577 | 0.77 | KDR (0.54) | KDRPDGFRBRETPLK4GAK | |
| SCHEMBL5015546 | 0.76 | KDR (0.53) | KDRPDGFRBRETPLK4GAK | |
| SCHEMBL5015492 | 0.76 | KDR (0.53) | KDRPDGFRBRETPLK4GAK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1309587-A1 | CINNOLINE COMPOUNDS | AstraZeneca AB (SE) | 2003-05-14 | — | — | EP | claimed |
| WO-2002012228-A1 | CINNOLINE COMPOUNDS | ASTRAZENECA AB (SE) | 2002-02-14 | — | — | WO | claimed |