Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 18/20 | 0.54 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6041576 | 0.98 | REN (0.53) | RENSLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL6041672 | 0.84 | REN (0.46) | REN | |
| SCHEMBL6949471 | 0.82 | REN (0.58) | RENSLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL7078301 | 0.81 | REN (0.44) | REN | |
| Hydrochloric Acid SCHEMBL6041239 | 0.81 | REN (0.57) | RENSLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL6042908 | 0.80 | REN (0.64) | REN | |
| Trifluoroacetic Acid SCHEMBL7562840 | 0.72 | REN (0.74) | REN | |
| Hydrochloric Acid SCHEMBL6043349 | 0.71 | REN (0.80) | REN | |
| SCHEMBL6042805 | 0.70 | REN (1.00) | REN | |
| Hydrochloric Acid SCHEMBL6041571 | 0.69 | REN (0.47) | RENSLC6A2SLC6A4SLC6A3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863875-B1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | HOFFMANN LA ROCHE (CH) | 2003-06-04 | — | — | EP | disclosed |
| EP-0863875-A1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | F. HOFFMANN-LA ROCHE AG (CH) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997009311-A1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | F. HOFFMANN-LA ROCHE AG (CH) | 1997-03-13 | — | — | WO | disclosed |