Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.59 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.59 |
| ▸ | IGF1R | P08069 | 1/20 | 0.59 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.59 |
| ▸ | GLB1 | P16278 | 1/20 | 0.59 |
| ▸ | CTRC | Q99895 | 1/20 | 0.59 |
| ▸ | SRC | P12931 | 3/20 | 0.55 |
| ▸ | CDK2 | P24941 | 2/20 | 0.53 |
| ▸ | KDR | P35968 | 1/20 | 0.52 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.50 |
| ▸ | FCER2 | P06734 | 1/20 | 0.50 |
| ▸ | SYK | P43405 | 1/20 | 0.50 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.50 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.50 |
| ▸ | APP | P05067 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.48 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.48 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7136913 | 0.88 | LRRK2 (0.57) | SRCCDK2KDRNTRK1FCER2 | |
| SCHEMBL7136883 | 0.87 | SRC (0.58) | PDGFRBSRCCDK2KDRNTRK1 | |
| SCHEMBL5365190 | 0.86 | PSEN1 (0.60) | PDGFRBSRCCDK2KDRAPP | |
| SCHEMBL5369843 | 0.86 | SRC (0.59) | PDGFRBSRCCDK2KDRNTRK1 | |
| SCHEMBL5365022 | 0.84 | SRC (0.55) | PDGFRBSRCCDK2KDRNTRK1 | |
| SCHEMBL5361448 | 0.84 | SYK (0.65) | SRCCDK2KDRNTRK1FCER2 | |
| SCHEMBL7132147 | 0.84 | SRC (0.55) | PDGFRBSRCCDK2KDRNTRK1 | |
| SCHEMBL7130343 | 0.84 | SRC (0.55) | SRCCDK2KDRNTRK1FCER2 | |
| SCHEMBL7135152 | 0.84 | SRC (0.55) | PDGFRBSRCCDK2KDRNTRK1 | |
| SCHEMBL7138289 | 0.84 | SRC (0.58) | PDGFRBSRCCDK2KDRNTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6506763-B2 | Useful in prevention and treatment of protein kinase related disorders such as cancer | SUGEN, INC. | 2003-01-14 | — | — | US | disclosed |
| EP-0984930-A1 | 2-INDOLINONE DERIVATIVES AS MODULATORS OF PROTEIN KINASE ACTIVITY | Sugen, Inc. (US) | 2000-03-15 | — | — | EP | disclosed |
| WO-1998050356-A1 | 2-INDOLINONE DERIVATIVES AS MODULATORS OF PROTEIN KINASE ACTIVITY | SUGEN, INC. (US) | 1998-11-12 | — | — | WO | disclosed |