Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | SRC | P12931 | 11/20 | 0.55 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.55 |
| ▸ | FCER2 | P06734 | 1/20 | 0.55 |
| ▸ | SYK | P43405 | 1/20 | 0.55 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.55 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.55 |
| ▸ | CDK2 | P24941 | 2/20 | 0.53 |
| ▸ | KDR | P35968 | 8/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 7/20 | 0.50 |
| ▸ | LCK | P06239 | 7/20 | 0.50 |
| ▸ | FYN | P06241 | 7/20 | 0.50 |
| ▸ | YES1 | P07947 | 7/20 | 0.50 |
| ▸ | FGFR1 | P11362 | 7/20 | 0.50 |
| ▸ | RET | P07949 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7132020 | 0.91 | MEN1 (0.58) | MEN1KMT2ASRCNTRK1FCER2 | |
| SCHEMBL7138258 | 0.87 | MEN1 (0.66) | MEN1KMT2ASRCNTRK1FCER2 | |
| SCHEMBL7136883 | 0.85 | SRC (0.58) | SRCNTRK1FCER2SYKNTRK3 | |
| SCHEMBL5362316 | 0.82 | SYK (0.60) | SRCNTRK1FCER2SYKNTRK3 | |
| SCHEMBL7133214 | 0.82 | MOGAT2 (0.56) | MEN1KMT2ASYKPDGFRBRET | |
| SCHEMBL5361802 | 0.81 | SRC (0.54) | MEN1KMT2ASRCNTRK1FCER2 | |
| SCHEMBL7132924 | 0.80 | NPC1 (0.60) | MEN1KMT2ASRCNTRK1FCER2 | |
| SCHEMBL5361428 | 0.80 | LRRK2 (0.64) | SRCNTRK1FCER2SYKNTRK3 | |
| SCHEMBL30453667 | 0.80 | PDPK1 (0.64) | SRCNTRK1FCER2SYKNTRK3 | |
| SCHEMBL5365048 | 0.80 | RET (0.67) | MEN1KMT2ASRCNTRK1SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6506763-B2 | Useful in prevention and treatment of protein kinase related disorders such as cancer | SUGEN, INC. | 2003-01-14 | — | — | US | disclosed |
| US-6133305-A | PREVENTION AND TREATMENT OF PROTEIN KINASE RELATED DISORDERS SUCH AS CANCER | SUGEN, INC. (US) | 2000-10-17 | — | — | US | disclosed |