Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB3 | P13945 | 18/20 | 0.79 |
| ▸ | ADRB1 | P08588 | 12/20 | 0.79 |
| ▸ | ADRB2 | P07550 | 7/20 | 0.79 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | GPR65 | Q8IYL9 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7555241 | 0.88 | ADRB3 (1.00) | ADRB3ADRB1ADRB2KDM4EMAPT | |
| SCHEMBL7139311 | 0.88 | ADRB3 (1.00) | ADRB3ADRB1ADRB2KDM4EMAPT | |
| SCHEMBL7139466 | 0.88 | ADRB3 (1.00) | ADRB3ADRB1ADRB2KDM4EMAPT | |
| SCHEMBL7561184 | 0.88 | ADRB3 (1.00) | ADRB3ADRB1ADRB2KDM4EMAPT | |
| SCHEMBL6987303 | 0.82 | ADRB3 (0.83) | ADRB3ADRB1ADRB2KDM4EMAPT | |
| SCHEMBL7090768 | 0.79 | ADRB3 (0.79) | ADRB3ADRB1ADRB2KDM4EMAPT | |
| SCHEMBL6987946 | 0.75 | GHSR (0.56) | ADRB3ADRB1ADRB2 | |
| SCHEMBL7138238 | 0.75 | ADRB3 (1.00) | ADRB3ADRB1ADRB2 | |
| SCHEMBL14593657 | 0.74 | EPHX1 (0.67) | KMT2A | |
| SCHEMBL14593707 | 0.74 | EPHX1 (0.67) | KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6506901-B2 | 1-(9H-Carbazol-4-yloxy)-3-((1-(7-trifluoromethyl-quinolin-4-yl) -piperidin-4-lmethyl)-amino)-propan-2-ol, for example; treating diabetes, urinary continence, atherosclerosis, gastrointestinal disorders, glaucoma | WYETH | 2003-01-14 | — | — | US | disclosed |