Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 4/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | RAF1 | P04049 | 3/20 | 0.54 |
| ▸ | APP | P05067 | 2/20 | 0.54 |
| ▸ | MAP1LC3B | Q9GZQ8 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | EGFR | P00533 | 1/20 | 0.54 |
| ▸ | ARAF | P10398 | 1/20 | 0.54 |
| ▸ | PIM1 | P11309 | 1/20 | 0.54 |
| ▸ | BRAF | P15056 | 1/20 | 0.54 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.54 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.54 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.54 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.54 |
| ▸ | MYOC | Q99972 | 1/20 | 0.54 |
| ▸ | DYRK4 | Q9NR20 | 1/20 | 0.54 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.54 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.54 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5363549 | 0.89 | MAPT (0.54) | NTRK1MAPTRAF1APPMAP1LC3B | |
| SCHEMBL7138923 | 0.85 | NPC1 (0.56) | NTRK1MAPTRAF1APPMAP1LC3B | |
| SCHEMBL7138293 | 0.85 | NPC1 (0.70) | NTRK1MAPTRAF1APPMAP1LC3B | |
| SCHEMBL7138605 | 0.83 | RAF1 (0.58) | NTRK1MAPTRAF1APPMAP1LC3B | |
| SCHEMBL7137647 | 0.81 | MAPT (0.58) | NTRK1MAPTRAF1APPMAP1LC3B | |
| SCHEMBL5363455 | 0.80 | MAPT (0.58) | NTRK1MAPTRAF1APPMAP1LC3B | |
| SCHEMBL7139500 | 0.80 | MAPT (0.63) | NTRK1MAPTRAF1APPMAP1LC3B | |
| SCHEMBL5373326 | 0.79 | MAPT (0.70) | NTRK1MAPTRAF1APPMAP1LC3B | |
| SCHEMBL7137009 | 0.79 | RAF1 (0.66) | NTRK1MAPTRAF1APPMAP1LC3B | |
| SCHEMBL7136535 | 0.78 | FLT3 (0.60) | NTRK1MAPTRAF1APPMAP1LC3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6506763-B2 | Useful in prevention and treatment of protein kinase related disorders such as cancer | SUGEN, INC. | 2003-01-14 | — | — | US | disclosed |