Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.70 |
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | FLT3 | P36888 | 3/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | RAF1 | P04049 | 3/20 | 0.53 |
| ▸ | APP | P05067 | 2/20 | 0.53 |
| ▸ | MAP1LC3B | Q9GZQ8 | 2/20 | 0.53 |
| ▸ | PLK4 | O00444 | 2/20 | 0.53 |
| ▸ | PLK1 | P53350 | 2/20 | 0.53 |
| ▸ | EGFR | P00533 | 1/20 | 0.53 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.53 |
| ▸ | ARAF | P10398 | 1/20 | 0.53 |
| ▸ | PIM1 | P11309 | 1/20 | 0.53 |
| ▸ | BRAF | P15056 | 1/20 | 0.53 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.53 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.53 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.53 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.53 |
| ▸ | MYOC | Q99972 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7138923 | 0.90 | NPC1 (0.56) | NPC1MEN1KMT2AFLT3MAPT | |
| SCHEMBL7138605 | 0.87 | RAF1 (0.58) | NPC1MEN1KMT2AFLT3MAPT | |
| SCHEMBL14674173 | 0.86 | FLT3 (0.76) | NPC1MEN1KMT2AFLT3PLK4 | |
| SCHEMBL14674172 | 0.86 | FLT3 (0.76) | NPC1MEN1KMT2AFLT3PLK4 | |
| SCHEMBL29638261 | 0.86 | FLT3 (0.76) | NPC1MEN1KMT2AFLT3PLK4 | |
| SCHEMBL7136535 | 0.85 | FLT3 (0.60) | NPC1MEN1KMT2AFLT3MAPT | |
| SCHEMBL5358648 | 0.85 | FLT3 (0.60) | NPC1MEN1KMT2AFLT3MAPT | |
| SCHEMBL7130967 | 0.85 | NTRK1 (0.54) | NPC1MEN1KMT2AFLT3MAPT | |
| SCHEMBL17179637 | 0.84 | MEN1 (0.76) | NPC1MEN1KMT2AFLT3MAPT | |
| SCHEMBL5359400 | 0.84 | PLK4 (0.70) | NPC1MEN1KMT2AFLT3MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6506763-B2 | Useful in prevention and treatment of protein kinase related disorders such as cancer | SUGEN, INC. | 2003-01-14 | — | — | US | disclosed |