Largazole

Largazole

SCHEMBL71330

CCCCCCCC(=O)SCC/C=C/[C@@H]1CC(=O)NCc2nc(cs2)C2=N[C@@](C)(CS2)C(=O)N[C@@H](C(C)C)C(=O)O1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 19/20 1.00
HDAC3 O15379 16/20 1.00
HDAC2 Q92769 14/20 1.00
HDAC6 Q9UBN7 9/20 1.00
NCOR2 Q9Y618 7/20 1.00
HDAC8 Q9BY41 7/20 1.00
HDAC10 Q969S8 7/20 1.00
HDAC4 P56524 6/20 1.00
HDAC9 Q9UKV0 2/20 1.00
UBA1 P22314 1/20 1.00
HDAC11 Q96DB2 2/20 0.79

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Largazole SCHEMBL7937167 1.00 HDAC1 (1.00) HDAC1HDAC3HDAC2HDAC6NCOR2
Largazole SCHEMBL2611944 1.00 HDAC1 (1.00) HDAC1HDAC3HDAC2HDAC6NCOR2
Largazole SCHEMBL31485751 1.00 HDAC1 (1.00) HDAC1HDAC3HDAC2HDAC6NCOR2
Largazole SCHEMBL91139 1.00 HDAC1 (1.00) HDAC1HDAC3HDAC2HDAC6NCOR2
Largazole SCHEMBL23760411 1.00 HDAC1 (1.00) HDAC1HDAC3HDAC2HDAC6NCOR2
Largazole SCHEMBL23760414 1.00 HDAC1 (1.00) HDAC1HDAC3HDAC2HDAC6NCOR2
Largazole SCHEMBL10314988 1.00 HDAC1 (1.00) HDAC1HDAC3HDAC2HDAC6NCOR2
Largazole SCHEMBL14973971 1.00 HDAC1 (1.00) HDAC1HDAC3HDAC2HDAC6NCOR2
Largazole SCHEMBL2611945 1.00 HDAC1 (1.00) HDAC1HDAC3HDAC2HDAC6NCOR2
SCHEMBL13453167 0.97 HDAC1 (0.94) HDAC1HDAC3HDAC2HDAC6NCOR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 458 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4695324-A1 BIO-ORTHOGONAL HYDROGELS FOR SUSTAINED RELEASE DRUG DELIVERY Ocular Therapeutix, Inc. (US) 2026-02-18 EP claimed
EP-4683964-A2 POLY(ETHYLENE GLYCOL) BASED DENDRIMER-LIKE HYPERBRANCHED MACROMOLECULES, METHODS OF PREPARATION AND USE THEREOF Ocular Therapeutix, Inc. (US) 2026-01-28 EP claimed
US-20250312347-A1 THERAPEUTIC BENEFIT OF SUBOPTIMALLY ADMINISTERED CHEMICAL COMPOUNDS BROWN DENNIS M (US) 2025-10-09 US claimed
US-20250144056-A1 ANTIMICROBIAL HOST DEFENSE PEPTIDE-INDUCING COMPOSITIONS AND METHODS OF PRODUCTION AND USE THEREOF BOARD OF REGENTS FOR THE OKLAHOMA AGRICULTURAL AND MECH COLLEGES (US) 2025-05-08 US claimed
CN-119923405-A Treatment or prevention of medical conditions associated with herpes virus infection 艾克西米恩生物技术股份有限公司 2025-05-02 CN claimed
WO-2025059442-A1 MODULATING PLANT RESPONSES TO STRESS AND GROWTH WITH CHEMICALS REMOTE EPIGENETICS INC. (US) 2025-03-20 WO claimed
WO-2024254217-A2 NOVEL BIOMARKERS FOR ANTITUMOR THERAPIES AND PRDX6 AS A THERAPEUTIC CANCER TARGET THE REGENTS OF THE UNIVERSITY OF COLORADO A BODY CORPORATE (US) 2024-12-12 WO claimed
WO-2024215661-A1 BIO-ORTHOGONAL HYDROGELS FOR SUSTAINED RELEASE DRUG DELIVERY OCULAR THERAPEUTIX, INC. (US) 2024-10-17 WO claimed
WO-2024197137-A2 POLY(ETHYLENE GLYCOL) BASED DENDRIMER-LIKE HYPERBRANCHED MACROMOLECULES, METHODS OF PREPARATION AND USE THEREOF OCULAR THERAPEUTIX, INC. (US) 2024-09-26 WO claimed
WO-2024192348-A2 METHODS OF TREATING HPV IN HIV-INFECTED PATIENTS OHIO STATE INNOVATION FOUNDATION (US) 2024-09-19 WO claimed
WO-2023147573-A2 ANTIMICROBIAL HOST DEFENSE PEPTIDE-INDUCING COMPOSITIONS AND METHODS OF PRODUCTION AND USE THEREOF BOARD OF REGENTS FOR THE OKLAHOMA AGRICULTURAL AND MECHANICAL COLLEGES (US) 2023-08-03 WO claimed
US-11701363-B2 Methods for treating viral disorders TRUSTEES OF BOSTON UNIVERSITY (US) 2023-07-18 US claimed
WO-2022257986-A1 USE OF CYP450 INHIBITOR IN INHIBITING OR KILLING MITES AND TREATING DRY EYE SYNDROME 广州岐微生物医药科技有限公司 2022-12-15 WO claimed
US-20220387546-A1 Methods For Treating And/Or Preventing Hypersomnias UNIVERSITE DE LAUSANNE (CH) 2022-12-08 US claimed
EP-4048685-A1 METHODS FOR TREATING AND/OR PREVENTING HYPERSOMNIAS Université de Lausanne (CH) 2022-08-31 EP claimed
US-20220249477-A1 METHODS AND COMPOSITIONS FOR TREATING VIRAL OR VIRALLY-INDUCED CONDITIONS VIRACTA THERAPEUTICS, INC. (US) 2022-08-11 US claimed
CN-114829386-A Method for treating and/or preventing hypersomnia 洛桑大学 2022-07-29 CN claimed
CN-110755425-B Application of Largazole in preparation of medicine for treating diseases caused by overexpression of Msi1 gene ectopy 中国农业大学 2022-06-24 CN claimed
CN-110117293-B Polyfluoro-substituted Largazole analogue, preparation method and application thereof 复旦大学 2022-05-10 CN claimed
WO-2022058405-A2 HISTONE DEACETYLASE INHIBITORS AND USES THEREOF IFOM - ISTITUTO FIRC DI ONCOLOGIA MOLECOLARE (IT) 2022-03-24 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250312347-A1 THERAPEUTIC BENEFIT OF SUBOPTIMALLY ADMINISTERED CHEMICAL COMPOUNDS UNG, DPYD, TPMT HDAC1 493/4885HDAC3 1117/4885HDAC2 601/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.