Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 19/20 | 1.00 |
| ▸ | HDAC3 | O15379 | 16/20 | 1.00 |
| ▸ | HDAC2 | Q92769 | 14/20 | 1.00 |
| ▸ | HDAC6 | Q9UBN7 | 9/20 | 1.00 |
| ▸ | NCOR2 | Q9Y618 | 7/20 | 1.00 |
| ▸ | HDAC8 | Q9BY41 | 7/20 | 1.00 |
| ▸ | HDAC10 | Q969S8 | 7/20 | 1.00 |
| ▸ | HDAC4 | P56524 | 6/20 | 1.00 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 1.00 |
| ▸ | UBA1 | P22314 | 1/20 | 1.00 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.79 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Largazole SCHEMBL7937167 | 1.00 | HDAC1 (1.00) | HDAC1HDAC3HDAC2HDAC6NCOR2 | |
| Largazole SCHEMBL2611944 | 1.00 | HDAC1 (1.00) | HDAC1HDAC3HDAC2HDAC6NCOR2 | |
| Largazole SCHEMBL31485751 | 1.00 | HDAC1 (1.00) | HDAC1HDAC3HDAC2HDAC6NCOR2 | |
| Largazole SCHEMBL91139 | 1.00 | HDAC1 (1.00) | HDAC1HDAC3HDAC2HDAC6NCOR2 | |
| Largazole SCHEMBL23760411 | 1.00 | HDAC1 (1.00) | HDAC1HDAC3HDAC2HDAC6NCOR2 | |
| Largazole SCHEMBL71330 | 1.00 | HDAC1 (1.00) | HDAC1HDAC3HDAC2HDAC6NCOR2 | |
| Largazole SCHEMBL23760414 | 1.00 | HDAC1 (1.00) | HDAC1HDAC3HDAC2HDAC6NCOR2 | |
| Largazole SCHEMBL10314988 | 1.00 | HDAC1 (1.00) | HDAC1HDAC3HDAC2HDAC6NCOR2 | |
| Largazole SCHEMBL14973971 | 1.00 | HDAC1 (1.00) | HDAC1HDAC3HDAC2HDAC6NCOR2 | |
| SCHEMBL13453167 | 0.97 | HDAC1 (0.94) | HDAC1HDAC3HDAC2HDAC6NCOR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10676504-B2 | Method for preparing largazole analogs and uses thereof | COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2020-06-09 | — | — | US | disclosed |
| US-20180044376-A1 | Method for Preparing Largazole Analogs and Uses Thereof | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2018-02-15 | — | — | US | disclosed |
| US-20180044376-A1 | Method for Preparing Largazole Analogs and Uses Thereof | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2018-02-15 | — | — | US | disclosed |
| US-9492434-B2 | Combination compositions and methods of treatment | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2016-11-15 | — | — | US | disclosed |
| US-20150210718-A1 | MACROCYCLIC COMPOUNDS AND METHODS OF TREATMENT | UNIV FLORIDA (US) | 2015-07-30 | — | — | US | disclosed |
| US-20140323450-A1 | COMBINATION COMPOSITIONS AND METHODS OF TREATMENT | University of Florida Research Founation (US) | 2014-10-30 | — | — | US | disclosed |
| US-8513290-B2 | Method for preparing largazole analogs and uses thereof | COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2013-08-20 | — | — | US | disclosed |
| US-8357708-B2 | Macrocyclic compounds and methods of treatment | University of Florida Resesarch Foundation, Inc. (US) | 2013-01-22 | — | — | US | disclosed |
| US-20120264794-A1 | Method for Preparing Largazole Analogs and Uses Thereof | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2012-10-18 | — | — | US | disclosed |
| US-20120264794-A1 | Method for Preparing Largazole Analogs and Uses Thereof | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2012-10-18 | — | — | US | disclosed |
| US-8217076-B2 | Method for preparing largazole analogs and uses thereof | COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2012-07-10 | — | — | US | disclosed |
| US-20120095065-A1 | MACROCYCLIC COMPOUNDS AND METHODS OF TREATMENT | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2012-04-19 | — | — | US | disclosed |
| US-20110123644-A1 | MACROCYCLIC COMPOUNDS AND METHODS OF TREATMENT | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION (US) | 2011-05-26 | — | — | US | disclosed |
| US-20100029731-A1 | Method for preparing largazole analogs and uses thereof | COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2010-02-04 | — | — | US | disclosed |
| WO-2010009334-A1 | METHOD FOR PREPARING LARGAZOLE ANALOGS AND USES THEREOF | COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2010-01-21 | — | — | WO | disclosed |
| WO-2009126315-A2 | MACROCYCLIC COMPOUNDS AND METHODS OF TREATMENT | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2009-10-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029731-A1 | Method for preparing largazole analogs and uses thereof | CYP51A1, ADPRS, LPXN | HDAC1 355/4885HDAC3 114/4885HDAC2 362/4885 |
| US-20120095065-A1 | MACROCYCLIC COMPOUNDS AND METHODS OF TREATMENT | MKI67, MCL1, MYC | HDAC1 157/4885HDAC3 79/4885HDAC2 525/4885 |
| US-10676504-B2 | Method for preparing largazole analogs and uses thereof | CYP51A1, ADPRS, LPXN | HDAC1 355/4885HDAC3 114/4885HDAC2 362/4885 |
| US-20140323450-A1 | COMBINATION COMPOSITIONS AND METHODS OF TREATMENT | NFATC1, MCL1, CKMT1A; CKMT1B | HDAC1 120/4885HDAC3 97/4885HDAC2 529/4885 |
| US-20120264794-A1 | Method for Preparing Largazole Analogs and Uses Thereof | CYP51A1, ADPRS, LPXN | HDAC1 355/4885HDAC3 114/4885HDAC2 362/4885 |
| US-20150210718-A1 | MACROCYCLIC COMPOUNDS AND METHODS OF TREATMENT | HDAC1, HDAC11, HDAC3 | HDAC1 1/4885HDAC3 3/4885HDAC2 9/4885 |
| US-20110123644-A1 | MACROCYCLIC COMPOUNDS AND METHODS OF TREATMENT | HDAC1, HDAC11, HDAC3 | HDAC1 1/4885HDAC3 3/4885HDAC2 9/4885 |
| US-20180044376-A1 | Method for Preparing Largazole Analogs and Uses Thereof | CYP51A1, ADPRS, LPXN | HDAC1 355/4885HDAC3 114/4885HDAC2 362/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.