Sugi Predict

Sugi Predict / Compounds / SCHEMBL713315

SCHEMBL713315

SCHEMBL713315

CC(C)Oc1cc(OCc2ccccc2)ccc1-c1nc2cc(-c3ccccc3Cl)cnc2[nH]1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PRMT5 O14744 3/20 0.38
▸ PTGES O14684 2/20 0.37
▸ MAPT P10636 5/20 0.36
▸ KDM4E B2RXH2 2/20 0.36
▸ MCL1 Q07820 1/20 0.35
▸ PDGFRB P09619 1/20 0.35
▸ PDGFRA P16234 1/20 0.35
▸ MAPK1 P28482 3/20 0.35
▸ NPSR1 Q6W5P4 2/20 0.35
▸ HSP90AA1 P07900 1/20 0.35
▸ TDP1 Q9NUW8 1/20 0.35
▸ FFAR1 O14842 2/20 0.35
▸ PPARD Q03181 2/20 0.35
▸ NR1H4 Q96RI1 2/20 0.35
▸ LMNA P02545 1/20 0.35
▸ GAA P10253 1/20 0.35
▸ SMO Q99835 1/20 0.35
▸ NOD2 Q9HC29 1/20 0.35
▸ TP53 P04637 1/20 0.34
▸ MDM2 Q00987 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL712000 0.93 PRMT5 (0.38) PRMT5PTGESMAPTKDM4EMCL1
SCHEMBL10206529 0.91 MAPT (0.41) MAPTKDM4EMCL1PDGFRBPDGFRA
SCHEMBL712826 0.90 MAP4K4 (0.43) PRMT5MAPTMCL1MAPK1NPSR1
SCHEMBL713547 0.90 PRMT5 (0.39) PRMT5MAPTKDM4EMCL1PDGFRB
SCHEMBL709187 0.90 MAPT (0.36) MAPTKDM4EMCL1PDGFRBPDGFRA
SCHEMBL720491 0.90 MAPT (0.46) PRMT5MAPTKDM4EPDGFRBPDGFRA
SCHEMBL710530 0.90 MAPT (0.42) MAPTKDM4EMCL1PDGFRBPDGFRA
SCHEMBL710291 0.88 FFAR1 (0.37) PRMT5MAPTKDM4EMCL1PDGFRB
SCHEMBL713393 0.88 GRIN1 (0.43) PRMT5MAPTKDM4EPDGFRBPDGFRA
SCHEMBL720489 0.88 MAPT (0.46) PRMT5MAPTKDM4EMCL1PDGFRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1940837-B1 IMIDAZOPYRIDINE COMPOUNDS TAKEDA PHARMACEUTICAL (JP) 2012-11-07 — — EP disclosed
US-8124617-B2 Imidazopyridine compounds TAKEDA SAN DIEGO, INC. (US) 2012-02-28 — — US disclosed
US-8124617-B2 Imidazopyridine compounds TAKEDA SAN DIEGO, INC. (US) 2012-02-28 — — US disclosed
US-8124617-B2 Imidazopyridine compounds TAKEDA SAN DIEGO, INC. (US) 2012-02-28 — — US disclosed
US-20100069431-A1 IMIDAZOPYRIDINE COMPOUNDS TAKEDA SAN DIEGO, INC. 2010-03-18 — — US disclosed
US-20100069431-A1 IMIDAZOPYRIDINE COMPOUNDS TAKEDA SAN DIEGO, INC. 2010-03-18 — — US disclosed
US-20100069431-A1 IMIDAZOPYRIDINE COMPOUNDS TAKEDA SAN DIEGO, INC. 2010-03-18 — — US disclosed
EP-1940837-A2 IMIDAZOPYRIDINE COMPOUNDS Takeda Pharmaceutical Company Limited (JP) 2008-07-09 — — EP disclosed
WO-2007028135-A2 IMIDAZOPYRIDINE COMPOUNDS TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2007-03-08 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100069431-A1 IMIDAZOPYRIDINE COMPOUNDS GCK, GCKR, KHK PRMT5 2373/4885PTGES 2068/4885MAPT 3003/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.