Sugi Predict

Sugi Predict / Compounds / SCHEMBL709187

SCHEMBL709187

SCHEMBL709187

CC(C)Oc1cc(OCc2ccccc2)ccc1-c1nc2cc(-c3ccccc3F)cnc2[nH]1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 6/20 0.36
▸ KDM4E B2RXH2 3/20 0.36
▸ MCL1 Q07820 1/20 0.35
▸ PDGFRB P09619 1/20 0.35
▸ PDGFRA P16234 1/20 0.35
▸ MAPK1 P28482 4/20 0.35
▸ NPSR1 Q6W5P4 4/20 0.35
▸ HSP90AA1 P07900 1/20 0.35
▸ TDP1 Q9NUW8 1/20 0.35
▸ FFAR1 O14842 1/20 0.35
▸ NOD2 Q9HC29 1/20 0.35
▸ POLB P06746 1/20 0.35
▸ MPO P05164 1/20 0.35
▸ GRM5 P41594 1/20 0.34
▸ PDE4B Q07343 2/20 0.34
▸ GRIN1 Q05586 1/20 0.34
▸ GRIN2B Q13224 1/20 0.34
▸ PDE10A Q9Y233 1/20 0.34
▸ PDE5A O76074 1/20 0.34
▸ PDE4A P27815 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10206529 0.91 MAPT (0.41) MAPTKDM4EMCL1PDGFRBPDGFRA
SCHEMBL713547 0.90 PRMT5 (0.39) MAPTKDM4EMCL1PDGFRBPDGFRA
SCHEMBL712059 0.90 MCL1 (0.40) MAPTKDM4EMCL1PDGFRBPDGFRA
SCHEMBL710530 0.90 MAPT (0.42) MAPTKDM4EMCL1PDGFRBPDGFRA
SCHEMBL713315 0.90 PRMT5 (0.38) MAPTKDM4EMCL1PDGFRBPDGFRA
SCHEMBL720491 0.90 MAPT (0.46) MAPTKDM4EPDGFRBPDGFRAMAPK1
SCHEMBL711273 0.90 GPR34 (0.40) MAPTKDM4EMCL1PDGFRBPDGFRA
SCHEMBL712420 0.89 SCD (0.42) MAPTKDM4EMCL1PDGFRBPDGFRA
SCHEMBL713393 0.88 GRIN1 (0.43) MAPTKDM4EPDGFRBPDGFRAMAPK1
SCHEMBL720489 0.88 MAPT (0.46) MAPTKDM4EMCL1PDGFRBPDGFRA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1940837-B1 IMIDAZOPYRIDINE COMPOUNDS TAKEDA PHARMACEUTICAL (JP) 2012-11-07 — — EP disclosed
US-8124617-B2 Imidazopyridine compounds TAKEDA SAN DIEGO, INC. (US) 2012-02-28 — — US disclosed
US-8124617-B2 Imidazopyridine compounds TAKEDA SAN DIEGO, INC. (US) 2012-02-28 — — US disclosed
US-8124617-B2 Imidazopyridine compounds TAKEDA SAN DIEGO, INC. (US) 2012-02-28 — — US disclosed
US-20100069431-A1 IMIDAZOPYRIDINE COMPOUNDS TAKEDA SAN DIEGO, INC. 2010-03-18 — — US disclosed
US-20100069431-A1 IMIDAZOPYRIDINE COMPOUNDS TAKEDA SAN DIEGO, INC. 2010-03-18 — — US disclosed
US-20100069431-A1 IMIDAZOPYRIDINE COMPOUNDS TAKEDA SAN DIEGO, INC. 2010-03-18 — — US disclosed
EP-1940837-A2 IMIDAZOPYRIDINE COMPOUNDS Takeda Pharmaceutical Company Limited (JP) 2008-07-09 — — EP disclosed
WO-2007028135-A2 IMIDAZOPYRIDINE COMPOUNDS TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2007-03-08 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100069431-A1 IMIDAZOPYRIDINE COMPOUNDS GCK, GCKR, KHK MAPT 3003/4885KDM4E 1923/4885MCL1 4054/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.