Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 10/20 | 0.57 |
| ▸ | DRD2 | P14416 | 3/20 | 0.55 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.55 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.55 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.55 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.55 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.55 |
| ▸ | HTR7 | P34969 | 2/20 | 0.55 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.55 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.55 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.55 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.55 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.54 |
| ▸ | DRD4 | P21917 | 1/20 | 0.54 |
| ▸ | FPR3 | P25089 | 1/20 | 0.54 |
| ▸ | HTR1D | P28221 | 1/20 | 0.54 |
| ▸ | HTR1B | P28222 | 1/20 | 0.54 |
| ▸ | GPR183 | P32249 | 1/20 | 0.54 |
| ▸ | HRH1 | P35367 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7195440 | 0.88 | HTR1A (0.63) | HTR1ADRD2SLC6A4HTR2A | |
| SCHEMBL6815311 | 0.83 | HTR1A (0.62) | HTR1ADRD2SLC6A4HTR2A | |
| SCHEMBL6819326 | 0.82 | HTR1A (0.65) | HTR1ADRD2HTR2A | |
| SCHEMBL6823577 | 0.81 | HTR1A (0.60) | HTR1ADRD2SLC6A4HTR2A | |
| SCHEMBL6920285 | 0.81 | HTR1A (0.61) | HTR1ADRD2SLC6A4HTR2A | |
| SCHEMBL6819734 | 0.80 | HTR1A (0.69) | HTR1ADRD2HTR2A | |
| SCHEMBL6819884 | 0.79 | HTR1A (0.69) | HTR1A | |
| SCHEMBL5201581 | 0.76 | HTR1A (0.63) | HTR1ADRD2KCNH2HTR6HTR2A | |
| SCHEMBL6919604 | 0.76 | HTR1A (0.67) | HTR1ADRD2ADRA2AADRA2CSLC6A2 | |
| SCHEMBL6819132 | 0.76 | HTR1A (0.59) | HTR1ADRD2SLC6A4KCNH2HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004041815-A1 | INDOLE DERIVATIVE WITH 5HT1A AFFINITY | MERCK PATENT GMBH (DE) | 2004-05-21 | — | — | WO | claimed |