Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 2/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.35 |
| ▸ | CCR5 | P51681 | 1/20 | 0.34 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.34 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7139327 | 1.00 | MAOB (0.39) | MAOBCHRNA7SLC6A4SLC6A2HRH3 | |
| SCHEMBL7133283 | 1.00 | MAOB (0.39) | MAOBCHRNA7SLC6A4SLC6A2HRH3 | |
| SCHEMBL7135913 | 0.81 | MAOB (0.38) | MAOBCHRNA7SLC6A4SLC6A2HRH3 | |
| SCHEMBL8534018 | 0.81 | MAOB (0.38) | MAOBCHRNA7SLC6A4SLC6A2HRH3 | |
| SCHEMBL7140321 | 0.81 | SLC6A2 (0.45) | MAOBCHRNA7SLC6A4SLC6A2HRH3 | |
| SCHEMBL7137289 | 0.81 | MAOB (0.38) | MAOBCHRNA7SLC6A4SLC6A2HRH3 | |
| SCHEMBL7136382 | 0.81 | SLC6A2 (0.45) | MAOBCHRNA7SLC6A4SLC6A2HRH3 | |
| SCHEMBL7132224 | 0.75 | CHRNA7 (0.33) | MAOBCHRNA7SLC6A4SLC6A2HRH3 | |
| SCHEMBL8791980 | 0.75 | SLC18A3 (0.39) | MAOBCHRNA7HRH3CARM1PRMT5 | |
| SCHEMBL4715366 | 0.73 | SLC6A2 (0.44) | CHRNA7SLC6A4SLC6A2HRH3L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6509476-B1 | Leukotriene antagonists; antiallergens, antiinflammatory agents, and antiasthmatic agents | THE UNIVERSITY OF EAST ANGLIA (GB) | 2003-01-21 | — | — | US | disclosed |
| US-6160120-A | Process for preparing n-benzyl indoles | ELI LILLY AND COMPANY (US) | 2000-12-12 | — | — | US | disclosed |
| US-5807866-A | Process for preparing N-benzyl indoles | THE UNIVERSITY OF EAST ANGLIA (GB) | 1998-09-15 | — | — | US | disclosed |
| EP-0775694-A2 | Process for preparing N-benzyl indoles | University of East Anglia (GB) | 1997-05-28 | — | — | EP | disclosed |