Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 12/20 | 0.61 |
| ▸ | SLC6A4 | P31645 | 11/20 | 0.61 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.51 |
| ▸ | CHRNG | P07510 | 1/20 | 0.51 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.51 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.51 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.51 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.51 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.51 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.51 |
| ▸ | CHRND | Q07001 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7133287 | 1.00 | SLC6A3 (0.61) | SLC6A3SLC6A4CHRNA1CHRNGITGA5 | |
| SCHEMBL7125476 | 0.88 | SLC6A3 (0.67) | SLC6A3SLC6A4CHRNA1CHRNGITGA5 | |
| SCHEMBL7125482 | 0.88 | SLC6A3 (0.67) | SLC6A3SLC6A4CHRNA1CHRNGITGA5 | |
| SCHEMBL7121103 | 0.84 | SLC6A3 (0.58) | SLC6A3SLC6A4SLC6A2 | |
| SCHEMBL6359095 | 0.82 | SLC6A3 (0.60) | SLC6A3SLC6A4CHRNA1CHRNGITGA5 | |
| SCHEMBL7036780 | 0.82 | SLC6A3 (0.60) | SLC6A3SLC6A4CHRNA1CHRNGITGA5 | |
| SCHEMBL6357049 | 0.82 | SLC6A3 (0.60) | SLC6A3SLC6A4CHRNA1CHRNGITGA5 | |
| SCHEMBL6363204 | 0.82 | SLC6A3 (0.60) | SLC6A3SLC6A4CHRNA1CHRNGITGA5 | |
| SCHEMBL6357051 | 0.82 | SLC6A3 (0.60) | SLC6A3SLC6A4CHRNA1CHRNGITGA5 | |
| SCHEMBL7131443 | 0.82 | SLC6A3 (0.68) | SLC6A3SLC6A4CHRNA1CHRNGITGA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6670375-B2 | Particularly, 8-aza-, 8-carbo- and 8-oxo- tropanes having 6-or 7-substituents; preferred are the dopamine transporter, the serotonin transporter and the norepinephrine transporter. | ORGANIX, INC. | 2003-12-30 | — | — | US | claimed |