Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | FLT3 | P36888 | 2/20 | 0.38 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | XBP1 | P17861 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.35 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | PLK4 | O00444 | 1/20 | 0.34 |
| ▸ | PLK1 | P53350 | 1/20 | 0.34 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.34 |
| ▸ | RAF1 | P04049 | 1/20 | 0.34 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7139764 | 0.90 | NPC1 (0.57) | NPC1KMT2AMEN1FLT3MAP1LC3B | |
| SCHEMBL7134446 | 0.88 | NPC1 (0.43) | NPC1KMT2AMEN1FLT3MAP1LC3B | |
| SCHEMBL5362288 | 0.86 | CES1 (0.39) | NPC1KMT2AMEN1FLT3MAP1LC3B | |
| SCHEMBL5365774 | 0.83 | IKBKB (0.41) | NPC1KMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL7136542 | 0.81 | FLT3 (0.43) | NPC1KMT2AMEN1FLT3MAP1LC3B | |
| SCHEMBL7136300 | 0.80 | MAP3K7 (0.45) | KMT2AMEN1MAP1LC3BALDH1A1MAPT | |
| SCHEMBL7134869 | 0.80 | SIRT1 (0.43) | NPC1KMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL7139735 | 0.80 | KMT2A (0.55) | NPC1KMT2AMEN1FLT3ALDH1A1 | |
| SCHEMBL5362880 | 0.80 | PLK4 (0.57) | KMT2AMEN1FLT3MAP1LC3BALDH1A1 | |
| SCHEMBL7140941 | 0.79 | MYC (0.43) | NPC1KMT2AMEN1FLT3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6506763-B2 | Useful in prevention and treatment of protein kinase related disorders such as cancer | SUGEN, INC. | 2003-01-14 | — | — | US | disclosed |