Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK4 | O00444 | 1/20 | 0.48 |
| ▸ | PLK1 | P53350 | 1/20 | 0.48 |
| ▸ | NAT1 | P18440 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | RAF1 | P04049 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | XBP1 | P17861 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.35 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.34 |
| ▸ | TAB1 | Q15750 | 1/20 | 0.34 |
| ▸ | XDH | P47989 | 1/20 | 0.34 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7135224 | 0.90 | MAP3K7 (0.38) | PLK4PLK1KMT2AMEN1RAF1 | |
| SCHEMBL7138169 | 0.88 | POLB (0.42) | KMT2AMEN1RAF1ALDH1A1NPSR1 | |
| SCHEMBL7139425 | 0.87 | KMT2A (0.49) | NAT1KMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL7132313 | 0.86 | GAA (0.45) | KMT2AMEN1MCL1TDP1MAPT | |
| SCHEMBL7132942 | 0.86 | PTP4A3 (0.45) | PLK4KMT2AMEN1MAPTSIRT1 | |
| SCHEMBL7138173 | 0.86 | TDP1 (0.39) | PLK4PLK1KMT2AMEN1ALDH1A1 | |
| SCHEMBL7138946 | 0.85 | NPC1 (0.48) | KMT2AMEN1RAF1ALDH1A1MCL1 | |
| SCHEMBL7134889 | 0.85 | DYRK1A (0.39) | KMT2AMEN1ALDH1A1TDP1MAPT | |
| SCHEMBL7138047 | 0.84 | LRRK2 (0.43) | KMT2AMEN1ALDH1A1MAPTSIRT1 | |
| SCHEMBL7139752 | 0.84 | MAP3K7 (0.39) | PLK4PLK1KMT2AMEN1RAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6506763-B2 | Useful in prevention and treatment of protein kinase related disorders such as cancer | SUGEN, INC. | 2003-01-14 | — | — | US | disclosed |
| EP-0984930-A1 | 2-INDOLINONE DERIVATIVES AS MODULATORS OF PROTEIN KINASE ACTIVITY | Sugen, Inc. (US) | 2000-03-15 | — | — | EP | disclosed |
| WO-1998050356-A1 | 2-INDOLINONE DERIVATIVES AS MODULATORS OF PROTEIN KINASE ACTIVITY | SUGEN, INC. (US) | 1998-11-12 | — | — | WO | disclosed |