Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.46 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.46 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.46 |
| ▸ | TTR | P02766 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.39 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.39 |
| ▸ | PLK4 | O00444 | 3/20 | 0.39 |
| ▸ | PLK1 | P53350 | 2/20 | 0.39 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | GALK1 | P51570 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7135677 | 0.89 | MDM2 (0.47) | SIRT1SIRT2SIRT3LRRK2PSEN1 | |
| SCHEMBL7134869 | 0.85 | SIRT1 (0.43) | SIRT1SIRT2SIRT3MDM2PLK4 | |
| SCHEMBL5365740 | 0.82 | PTPN1 (0.51) | LRRK2MDM2PLK4PLK1RAF1 | |
| SCHEMBL5365556 | 0.81 | SIRT1 (0.46) | SIRT1SIRT2SIRT3LRRK2PSEN1 | |
| SCHEMBL7132034 | 0.81 | LRRK2 (0.50) | SIRT1SIRT2SIRT3LRRK2PSEN1 | |
| SCHEMBL5361431 | 0.80 | METAP1 (0.54) | SIRT1SIRT2SIRT3LRRK2PSEN1 | |
| SCHEMBL5368618 | 0.80 | ERN1 (0.46) | SIRT1SIRT2SIRT3LRRK2PSEN1 | |
| SCHEMBL5363102 | 0.80 | SIRT1 (0.46) | SIRT1SIRT2SIRT3LRRK2PSEN1 | |
| SCHEMBL7133846 | 0.80 | SIRT1 (0.39) | SIRT1SIRT2SIRT3TTRLRRK2 | |
| SCHEMBL5362880 | 0.80 | PLK4 (0.57) | SIRT1SIRT2SIRT3LRRK2PLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6506763-B2 | Useful in prevention and treatment of protein kinase related disorders such as cancer | SUGEN, INC. | 2003-01-14 | — | — | US | disclosed |