Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | MAOB | P27338 | 4/20 | 0.43 |
| ▸ | TLR4 | O00206 | 1/20 | 0.43 |
| ▸ | TLR2 | O60603 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | AR | P10275 | 1/20 | 0.42 |
| ▸ | CTSV | O60911 | 1/20 | 0.41 |
| ▸ | CTSL | P07711 | 1/20 | 0.41 |
| ▸ | PTGES | O14684 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7135777 | 1.00 | BACE1 (0.48) | BACE1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL7138334 | 0.87 | BACE1 (0.49) | BACE1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL14191569 | 0.86 | BACE1 (0.50) | BACE1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL5139856 | 0.86 | BACE1 (0.50) | BACE1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL7084801 | 0.81 | BACE1 (0.47) | BACE1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL28855392 | 0.76 | BACE1 (0.46) | BACE1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL3235424 | 0.76 | BACE1 (0.59) | BACE1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL1663438 | 0.76 | MEN1 (0.57) | BACE1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL30832846 | 0.76 | MEN1 (0.57) | BACE1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL1061802 | 0.75 | MAPT (0.56) | BACE1MEN1KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6608049-B2 | Indazoles | BAYER AKTIENGESELLSCHAFT (DE) | 2003-08-19 | — | — | US | disclosed |
| EP-1324987-A1 | INDAZOLES WITH THYROID HORMON LIKE ACTIVITY, A PROCESS FOR ITS PREPARATION AND ITS USE IN PHARMACEUTICAL COMPOSITIONS | Bayer Aktiengesellschaft (DE) | 2003-07-09 | — | — | EP | disclosed |
| US-20020193610-A1 | Indazoles | BAYER AKTIENGESELLSCHAFT (DE) | 2002-12-19 | — | — | US | disclosed |
| WO-2002022586-A1 | INDAZOLES HAVING AN ACTION SIMILAR TO THAT OF A THYROID HORMONE, METHOD FOR THE PRODUCTION THEREOF, AND THEIR USE IN MEDICAMENTS | BAYER AKTIENGESELLSCHAFT (DE) | 2002-03-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020193610-A1 | Indazoles | CYP3A43, CYP3A5, CYP3A4 | BACE1 787/4885MEN1 2440/4885KMT2A 3716/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.