Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 3/20 | 0.44 |
| ▸ | TLR4 | O00206 | 1/20 | 0.44 |
| ▸ | TLR2 | O60603 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | AR | P10275 | 1/20 | 0.43 |
| ▸ | CTSV | O60911 | 2/20 | 0.42 |
| ▸ | CTSL | P07711 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | PTGES | O14684 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14191569 | 1.00 | BACE1 (0.50) | BACE1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL7138334 | 0.87 | BACE1 (0.49) | BACE1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL7135777 | 0.86 | BACE1 (0.48) | BACE1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL7135779 | 0.86 | BACE1 (0.48) | BACE1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL7084801 | 0.82 | BACE1 (0.47) | BACE1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL6372335 | 0.81 | BACE1 (0.60) | BACE1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL14218374 | 0.81 | MAPT (0.50) | MEN1KMT2ANPC1RAB9ATLR4 | |
| SCHEMBL20921416 | 0.78 | AKR1C3 (0.44) | BACE1NPC1RAB9AMAPTLMNA | |
| SCHEMBL5139366 | 0.78 | BACE1 (0.54) | BACE1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL3235424 | 0.78 | BACE1 (0.59) | BACE1MEN1KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1378505-B1 | METHOD OF SYNTHESIZING CAMPTOTHECIN-RELATING COMPOUNDS | YAKULT HONSHA KK (JP) | 2014-11-05 | — | — | EP | disclosed |
| US-7378555-B2 | Method of synthesizing camptothecin-relating compounds | KABUSHIKI KAISHA YAKULT HONSHA (JP) | 2008-05-27 | — | — | US | disclosed |
| US-20070010674-A1 | Method of synthesizing camptothecin-relating compounds | KABUSHIKI KAISHA YAKULT HONSHA (JP) | 2007-01-11 | — | — | US | disclosed |
| US-7126000-B2 | Method of synthesizing camptothecin-relating compounds | KABUSHIKI KAISHA YAKULT HONSHA (JP) | 2006-10-24 | — | — | US | disclosed |
| US-20040106830-A1 | Method of synthesizing camptothecin-relating compounds | KABUSHIKI KAISHA YAKULT HONSHA (JP) | 2004-06-03 | — | — | US | disclosed |
| EP-1378505-A1 | METHOD OF SYNTHESIZING CAMPTOTHECIN-RELATING COMPOUNDS | Kabushiki Kaisha Yakult Honsha (JP) | 2004-01-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070010674-A1 | Method of synthesizing camptothecin-relating compounds | PAICS, DHPS, TOP2A | BACE1 2335/4885MEN1 2581/4885KMT2A 2593/4885 |
| US-20040106830-A1 | Method of synthesizing camptothecin-relating compounds | PAICS, DHPS, TOP2A | BACE1 2493/4885MEN1 2555/4885KMT2A 2454/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.