Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 4/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5358202 | 0.85 | PDGFRB (0.45) | ALDH1A1POLBKMT2AABL1RET | |
| SCHEMBL7136788 | 0.82 | PDGFRB (0.58) | ALDH1A1POLBKMT2AABL1RET | |
| SCHEMBL5362213 | 0.79 | MEN1 (0.33) | ALDH1A1KMT2APDGFRBFGFR1KDR | |
| SCHEMBL7131038 | 0.78 | NPSR1 (0.34) | ALDH1A1POLBKMT2ARAB9ANPC1 | |
| SCHEMBL5358435 | 0.74 | KDR (0.53) | ALDH1A1POLBKMT2AABL1RET | |
| SCHEMBL7137028 | 0.73 | MAOB (0.38) | ALDH1A1POLBKMT2AABL1RET | |
| SCHEMBL5991909 | 0.73 | ABL1 (0.45) | ALDH1A1POLBKMT2AABL1RET | |
| SCHEMBL5989093 | 0.73 | ALDH1A1 (0.42) | ALDH1A1POLBKMT2AABL1RET | |
| SCHEMBL5988621 | 0.72 | KDR (0.52) | ALDH1A1POLBKMT2AABL1RET | |
| SCHEMBL5990240 | 0.72 | PDGFRB (0.51) | ALDH1A1POLBKMT2AABL1RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6506763-B2 | Useful in prevention and treatment of protein kinase related disorders such as cancer | SUGEN, INC. | 2003-01-14 | — | — | US | disclosed |