Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP1LC3B | Q9GZQ8 | 3/20 | 0.57 |
| ▸ | LRRK2 | Q5S007 | 7/20 | 0.55 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.52 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.52 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.52 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.52 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.52 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.52 |
| ▸ | RAF1 | P04049 | 6/20 | 0.52 |
| ▸ | PLK4 | O00444 | 2/20 | 0.50 |
| ▸ | EGFR | P00533 | 2/20 | 0.49 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.49 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.49 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.49 |
| ▸ | ARAF | P10398 | 1/20 | 0.49 |
| ▸ | PIM1 | P11309 | 1/20 | 0.49 |
| ▸ | BRAF | P15056 | 1/20 | 0.49 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.49 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.49 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5358971 | 0.92 | MAP1LC3B (0.70) | MAP1LC3BLRRK2PSEN1PSEN2APH1B | |
| SCHEMBL7133928 | 0.89 | LRRK2 (0.53) | MAP1LC3BLRRK2PSEN1PSEN2APH1B | |
| SCHEMBL5368689 | 0.88 | LRRK2 (0.69) | MAP1LC3BLRRK2PSEN1PSEN2APH1B | |
| SCHEMBL5362863 | 0.85 | ERBB2 (0.65) | MAP1LC3BLRRK2PSEN1PSEN2APH1B | |
| SCHEMBL5357809 | 0.85 | EGFR (0.71) | MAP1LC3BLRRK2PSEN1PSEN2APH1B | |
| SCHEMBL7133366 | 0.84 | NTRK1 (0.53) | LRRK2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL5370082 | 0.84 | LRRK2 (0.70) | MAP1LC3BLRRK2PSEN1PSEN2APH1B | |
| SCHEMBL5367874 | 0.84 | LRRK2 (0.54) | LRRK2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL5361803 | 0.84 | LRRK2 (0.65) | LRRK2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7133855 | 0.83 | ERBB2 (0.53) | LRRK2PSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6506763-B2 | Useful in prevention and treatment of protein kinase related disorders such as cancer | SUGEN, INC. | 2003-01-14 | — | — | US | disclosed |