Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.61 |
| ▸ | APP | P05067 | 2/20 | 0.61 |
| ▸ | SNCA | P37840 | 2/20 | 0.61 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.57 |
| ▸ | GSK3B | P49841 | 6/20 | 0.56 |
| ▸ | METAP1 | P53582 | 1/20 | 0.52 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.51 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.50 |
| ▸ | JAK3 | P52333 | 1/20 | 0.50 |
| ▸ | RET | P07949 | 1/20 | 0.48 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.48 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.48 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.48 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.48 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.48 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7140932 | 0.84 | PSEN1 (0.62) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL5366866 | 0.84 | NOX4 (0.58) | MAPTAPPSNCANOX4GSK3B | |
| SCHEMBL5367333 | 0.84 | NOX4 (0.58) | MAPTAPPSNCANOX4GSK3B | |
| SCHEMBL5369296 | 0.84 | NOX4 (0.58) | MAPTAPPSNCANOX4GSK3B | |
| SCHEMBL7137564 | 0.83 | PSEN1 (0.52) | MAPTAPPSNCAPDGFRBRET | |
| SCHEMBL7133824 | 0.83 | PSEN1 (0.52) | MAPTAPPSNCARETPSEN1 | |
| SCHEMBL5361803 | 0.83 | LRRK2 (0.65) | PDGFRBJAK3RETPSEN1PSEN2 | |
| SCHEMBL5357872 | 0.83 | NOX4 (0.43) | MAPTAPPSNCANOX4GSK3B | |
| SCHEMBL7134346 | 0.81 | RAF1 (0.57) | SIRT2PDGFRBRETPSEN1PSEN2 | |
| SCHEMBL7139546 | 0.81 | PSEN1 (0.49) | MAPTAPPSNCARETPSEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6506763-B2 | Useful in prevention and treatment of protein kinase related disorders such as cancer | SUGEN, INC. | 2003-01-14 | — | — | US | disclosed |