Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.48 |
| ▸ | PIM1 | P11309 | 1/20 | 0.48 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.48 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.48 |
| ▸ | APP | P05067 | 1/20 | 0.46 |
| ▸ | PSD | A5PKW4 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | PLK4 | O00444 | 1/20 | 0.44 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7139935 | 0.92 | NTRK1 (0.56) | MEN1KMT2ANTRK1ALDH1A1MAPT | |
| SCHEMBL7137585 | 0.85 | NTRK1 (0.56) | MEN1KMT2ANTRK1ALDH1A1MAPT | |
| SCHEMBL5377009 | 0.85 | CISD1 (0.48) | MEN1KMT2ANTRK1POLBPIM1 | |
| SCHEMBL7133868 | 0.84 | PIM1 (0.45) | MEN1KMT2ANTRK1ALDH1A1MAPT | |
| SCHEMBL7135649 | 0.83 | NTRK1 (0.53) | MEN1KMT2ANTRK1NPC1RAB9A | |
| SCHEMBL7139478 | 0.83 | ADAMTS5 (0.55) | MEN1KMT2ANTRK1POLBNPC1 | |
| SCHEMBL7135159 | 0.83 | LRRK2 (0.48) | NTRK1LRRK2PIM1PIM2PLK4 | |
| SCHEMBL7134041 | 0.82 | ADAMTS5 (0.53) | MEN1KMT2ANTRK1POLBNPC1 | |
| SCHEMBL5358437 | 0.82 | LRRK2 (0.49) | MEN1KMT2ANTRK1POLBLRRK2 | |
| SCHEMBL7139028 | 0.82 | NTRK1 (0.52) | MEN1KMT2ANTRK1ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6506763-B2 | Useful in prevention and treatment of protein kinase related disorders such as cancer | SUGEN, INC. | 2003-01-14 | — | — | US | disclosed |