Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 5/20 | 0.51 |
| ▸ | PSEN2 | P49810 | 5/20 | 0.51 |
| ▸ | APH1B | Q8WW43 | 5/20 | 0.51 |
| ▸ | NCSTN | Q92542 | 5/20 | 0.51 |
| ▸ | APH1A | Q96BI3 | 5/20 | 0.51 |
| ▸ | PSENEN | Q9NZ42 | 5/20 | 0.51 |
| ▸ | LRRK2 | Q5S007 | 7/20 | 0.49 |
| ▸ | RAF1 | P04049 | 2/20 | 0.46 |
| ▸ | PLK4 | O00444 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.43 |
| ▸ | ULK1 | O75385 | 1/20 | 0.43 |
| ▸ | KIF15 | Q9NS87 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7140932 | 0.88 | PSEN1 (0.62) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7136650 | 0.85 | LRRK2 (0.61) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7135663 | 0.85 | ADAMTS5 (0.51) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7133803 | 0.84 | LRRK2 (0.54) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7133824 | 0.84 | PSEN1 (0.52) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7137564 | 0.84 | PSEN1 (0.52) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL5361803 | 0.84 | LRRK2 (0.65) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7139415 | 0.83 | EGFR (0.60) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7134346 | 0.82 | RAF1 (0.57) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL5468627 | 0.82 | LRRK2 (0.71) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6506763-B2 | Useful in prevention and treatment of protein kinase related disorders such as cancer | SUGEN, INC. | 2003-01-14 | — | — | US | disclosed |