Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 10/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.45 |
| ▸ | NTSR1 | P30989 | 2/20 | 0.45 |
| ▸ | XBP1 | P17861 | 1/20 | 0.45 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 8/20 | 0.41 |
| ▸ | PKM | P14618 | 6/20 | 0.41 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | HTT | P42858 | 4/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7139714 | 0.82 | MAPT (0.40) | MAPTKMT2AALDH1A1MAPK1NTSR1 | |
| SCHEMBL7131337 | 0.81 | KDR (0.51) | MAPTKMT2AALDH1A1MAPK1NTSR1 | |
| SCHEMBL7135755 | 0.81 | KMT2A (0.53) | MAPTKMT2AALDH1A1MAPK1NTSR1 | |
| SCHEMBL7134821 | 0.81 | KMT2A (0.43) | MAPTKMT2AALDH1A1MAPK1MEN1 | |
| SCHEMBL7137624 | 0.80 | KMT2A (0.48) | MAPTKMT2AALDH1A1MAPK1NTSR1 | |
| SCHEMBL7136101 | 0.79 | RET (0.44) | KMT2AMEN1HPGDGAAPOLB | |
| SCHEMBL7130491 | 0.79 | KMT2A (0.48) | MAPTKMT2AALDH1A1MAPK1NTSR1 | |
| SCHEMBL7135552 | 0.79 | ERBB2 (0.34) | MAPTKMT2AALDH1A1MAPK1NTSR1 | |
| SCHEMBL7138169 | 0.78 | POLB (0.42) | MAPTKMT2AALDH1A1MAPK1NTSR1 | |
| SCHEMBL7134889 | 0.78 | DYRK1A (0.39) | MAPTKMT2AALDH1A1MAPK1NTSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6506763-B2 | Useful in prevention and treatment of protein kinase related disorders such as cancer | SUGEN, INC. | 2003-01-14 | — | — | US | disclosed |
| EP-0984930-A1 | 2-INDOLINONE DERIVATIVES AS MODULATORS OF PROTEIN KINASE ACTIVITY | Sugen, Inc. (US) | 2000-03-15 | — | — | EP | disclosed |
| WO-1998050356-A1 | 2-INDOLINONE DERIVATIVES AS MODULATORS OF PROTEIN KINASE ACTIVITY | SUGEN, INC. (US) | 1998-11-12 | — | — | WO | disclosed |