Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 8/20 | 0.48 |
| ▸ | MEN1 | O00255 | 6/20 | 0.48 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.40 |
| ▸ | ALPL | P05186 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | ALPI | P09923 | 1/20 | 0.39 |
| ▸ | ALPG | P10696 | 1/20 | 0.39 |
| ▸ | G6PD | P11413 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 4/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.33 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.33 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.33 |
| ▸ | RAF1 | P04049 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | PKM | P14618 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7134821 | 0.88 | KMT2A (0.43) | KMT2AMEN1ERBB2ALPLHSP90AA1 | |
| SCHEMBL7135755 | 0.88 | KMT2A (0.53) | KMT2AMEN1ERBB2ALPLHSP90AA1 | |
| SCHEMBL7132947 | 0.83 | ERBB2 (0.57) | KMT2AMEN1ERBB2ALPLHSP90AA1 | |
| SCHEMBL7138194 | 0.83 | EGFR (0.51) | KMT2AMEN1ERBB2ALPLHSP90AA1 | |
| SCHEMBL5368564 | 0.82 | MEN1 (0.50) | KMT2AMEN1ERBB2ALPLHSP90AA1 | |
| SCHEMBL7136163 | 0.81 | MEN1 (0.55) | KMT2AMEN1ERBB2ALPLHSP90AA1 | |
| SCHEMBL7135552 | 0.80 | ERBB2 (0.34) | KMT2AMEN1ERBB2ALPLHSP90AA1 | |
| SCHEMBL7136390 | 0.79 | MAPT (0.46) | KMT2AMEN1POLBMAPTALDH1A1 | |
| SCHEMBL7136076 | 0.79 | LRRK2 (0.42) | SIRT1SIRT2SIRT3PSEN1PSEN2 | |
| SCHEMBL7139714 | 0.79 | MAPT (0.40) | KMT2AMEN1ERBB2ALPLHSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6506763-B2 | Useful in prevention and treatment of protein kinase related disorders such as cancer | SUGEN, INC. | 2003-01-14 | — | — | US | disclosed |