Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 10/20 | 0.47 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2867854 | 0.83 | CRHR1 (0.45) | CRHR1 | |
| SCHEMBL2867822 | 0.81 | CRHR1 (0.55) | CRHR1DPP4CYP3A4 | |
| SCHEMBL7136995 | 0.79 | CRHR1 (0.45) | CRHR1 | |
| SCHEMBL2874007 | 0.79 | CRHR1 (0.53) | CRHR1DPP4CYP3A4 | |
| SCHEMBL2874339 | 0.78 | CRHR1 (0.52) | CRHR1DPP4CYP3A4 | |
| SCHEMBL2871753 | 0.78 | CRHR1 (0.52) | CRHR1DPP4CYP3A4 | |
| SCHEMBL2869314 | 0.78 | CNR1 (0.46) | CRHR1DPP4 | |
| SCHEMBL7081174 | 0.78 | DPP4 (0.43) | CRHR1EGLN2DPP4 | |
| SCHEMBL2872388 | 0.77 | CRHR1 (0.41) | CRHR1EGLN2DPP4 | |
| SCHEMBL7137016 | 0.77 | CRHR1 (0.44) | CRHR1EGLN2DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030220342-A1 | Imidazo[1, 2-a] pyrazines for the treatment of irritable bowel syndrome | BAKTHAVATCHALAM RAJAGOPAL (US) | 2003-11-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030220342-A1 | Imidazo[1, 2-a] pyrazines for the treatment of irritable bowel syndrome | SCN5A, HRH2, CHRNA5 | CRHR1 64/4885EGLN2 3887/4885DPP4 4188/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.