Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.41 |
| ▸ | NPC1 | O15118 | 5/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.40 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.40 |
| ▸ | LTA4H | P09960 | 7/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7140981 | 0.88 | MC4R (0.40) | RAB9ANPC1TP53LMNALTA4H | |
| SCHEMBL7143022 | 0.79 | TDP1 (0.30) | — | |
| SCHEMBL7143941 | 0.78 | MEN1 (0.31) | LMNAKMT2AALDH1A1 | |
| SCHEMBL8067798 | 0.76 | HDAC1 (0.30) | — | |
| SCHEMBL7138487 | 0.74 | MAPT (0.32) | TP53 | |
| SCHEMBL7143865 | 0.74 | MAPT (0.32) | TP53 | |
| SCHEMBL7137225 | 0.74 | MAPT (0.32) | TP53 | |
| SCHEMBL7139629 | 0.73 | LTA4H (0.46) | RAB9ANPC1SMN1; SMN2TP53LMNA | |
| SCHEMBL7139624 | 0.73 | LTA4H (0.46) | RAB9ANPC1SMN1; SMN2TP53LMNA | |
| SCHEMBL7141153 | 0.72 | PSEN1 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0966464-B1 | SUBSTITUTED 2,4-DIAMINOPYRIMIDINES | BASILEA PHARMACEUTICA AG (CH) | 2003-05-28 | — | — | EP | disclosed |
| US-6114330-A | BACTERICIDES | HOFFMANN-LA ROCHE INC. (US) | 2000-09-05 | — | — | US | disclosed |