Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 19/20 | 0.69 |
| ▸ | DHODH | Q02127 | 2/20 | 0.62 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.60 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.60 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.60 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.60 |
| ▸ | PLK4 | O00444 | 1/20 | 0.59 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.59 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.59 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.59 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.59 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.59 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.59 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.59 |
| ▸ | PIM1 | P11309 | 1/20 | 0.59 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.59 |
| ▸ | PRKACA | P17612 | 1/20 | 0.59 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.59 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.59 |
| ▸ | CLK2 | P49760 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29180029 | 0.85 | PARP1 (0.76) | PARP1DHODHPLA2G2AALOX15PTGS2 | |
| SCHEMBL30811249 | 0.85 | PARP1 (0.76) | PARP1DHODHPLA2G2AALOX15PTGS2 | |
| SCHEMBL6384519 | 0.84 | PARP1 (0.49) | PARP1DHODHPLA2G2AALOX15PTGS2 | |
| SCHEMBL7138966 | 0.84 | PARP1 (0.77) | PARP1DHODHPLA2G2AALOX15PTGS2 | |
| SCHEMBL29180021 | 0.83 | PARP1 (0.73) | PARP1DHODHPLA2G2AALOX15PTGS2 | |
| SCHEMBL3150801 | 0.83 | PARP1 (0.65) | PARP1DHODHPARP2PLK4MAPK13 | |
| SCHEMBL7137491 | 0.83 | PARP1 (0.47) | PARP1DHODHPLA2G2AALOX15PTGS2 | |
| SCHEMBL7139354 | 0.82 | PARP1 (0.83) | PARP1DHODHPLA2G2AALOX15PTGS2 | |
| SCHEMBL7131923 | 0.82 | PARP1 (0.79) | PARP1DHODHPLA2G2AALOX15PTGS2 | |
| SCHEMBL7137742 | 0.82 | PARP1 (1.00) | PARP1DHODHPLA2G2AALOX15PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6509365-B1 | 2-phenylbenzimidazoles and 2-phenylindoles, and production and use thereof | BASF AKTIENGESELLSCHAFT (DE) | 2003-01-21 | — | — | US | disclosed |