Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 18/20 | 0.47 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.40 |
| ▸ | DHODH | Q02127 | 2/20 | 0.40 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7138977 | 0.84 | PARP1 (0.50) | PARP1DHODH | |
| SCHEMBL7137488 | 0.83 | PARP1 (0.69) | PARP1CHEK2DHODHPLA2G2AALOX15 | |
| SCHEMBL7131933 | 0.82 | PARP1 (0.54) | PARP1CHEK2DHODHPLA2G2AALOX15 | |
| SCHEMBL7141044 | 0.78 | PARP1 (0.48) | PARP1 | |
| SCHEMBL7135402 | 0.77 | PARP1 (0.58) | PARP1CHEK2DHODH | |
| SCHEMBL2149454 | 0.77 | PARP1 (0.63) | PARP1CHEK2DHODHPLA2G2AALOX15 | |
| SCHEMBL3579908 | 0.77 | PARP1 (0.61) | PARP1CHEK2DHODH | |
| SCHEMBL6809996 | 0.75 | PKN1 (0.63) | PARP1CHEK2DHODHALOX15 | |
| SCHEMBL7583436 | 0.73 | PARP1 (0.66) | PARP1CHEK2DHODH | |
| SCHEMBL7136552 | 0.73 | PARP1 (0.52) | PARP1DHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6509365-B1 | 2-phenylbenzimidazoles and 2-phenylindoles, and production and use thereof | BASF AKTIENGESELLSCHAFT (DE) | 2003-01-21 | — | — | US | disclosed |