SCHEMBL7137668

SCHEMBL7137668

C1=CN(Cc2ccccc2)C(c2ccccc2)N1Cc1ccccc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 1/20 0.41
TP53 P04637 1/20 0.41
MDM2 Q00987 1/20 0.41
ELANE P08246 2/20 0.40
CALM1 P0DP23 1/20 0.40
F2 P00734 1/20 0.40
PLG P00747 1/20 0.40
CTSG P08311 1/20 0.40
CMA1 P23946 1/20 0.40
CTRC Q99895 1/20 0.40
HPGD P15428 1/20 0.40
TSHR P16473 1/20 0.40
CYP19A1 P11511 2/20 0.39
RECQL P46063 1/20 0.39
ABCB1 P08183 1/20 0.39
MEN1 O00255 1/20 0.38
KMT2A Q03164 1/20 0.38
EHMT2 Q96KQ7 1/20 0.38
GSK3A P49840 1/20 0.38
GSK3B P49841 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5284758 0.91 ELANE (0.37) SIGMAR1TP53MDM2ELANEF2
SCHEMBL5297033 0.88 DRD2 (0.39) TP53MDM2ELANEMEN1KMT2A
SCHEMBL5296270 0.87 MC4R (0.38) SIGMAR1TP53MDM2ELANEF2
SCHEMBL5302798 0.85 ABL1 (0.39) SIGMAR1HPGD
SCHEMBL5294780 0.83 KCNH2 (0.40) CYP19A1MEN1KMT2A
SCHEMBL5328384 0.82 KMT2A (0.36) TP53MDM2ELANETSHRCYP19A1
SCHEMBL5822124 0.82 KCNH2 (0.43) CYP19A1MEN1KMT2A
SCHEMBL5305527 0.82 KCNH2 (0.43) CYP19A1MEN1KMT2A
SCHEMBL5810791 0.82 KCNH2 (0.43) CYP19A1MEN1KMT2A
SCHEMBL5304385 0.82 KCNH2 (0.43) CYP19A1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101514256-A Resin molding material TEIJIN CHEMICALS LTD (JP) 2009-08-26 CN disclosed
CN-1212344-C Branched polyolefin, process for producing the same, and thermoplastic resin composition containing branched polyolefin MITSUI CHEMICALS INC (JP) 2005-07-27 CN disclosed
EP-0641807-B1 Olefin polymerization catalyst and process for preparing polypropylene and a propylene block copolymer MITSUI CHEMICALS INC (JP) 2003-06-04 EP disclosed
US-6537942-B2 Olefin polymerization catalysts are formed from: a contact product obtained by contacting a solid titanium compound, an organometallic compound, a specific organosilicon compound and a specific polyether compound MITSUI CHEMICALS INC (JP) 2003-03-25 US disclosed
US-6521560-B1 Free from elimination of titanium when washed with hexane at room temperature; high stereoregularity; high activity; contains magnesium, halogen and an electron donor MITSUI CHEMICALS INC. (JP) 2003-02-18 US disclosed
CN-1392886-A Branched polyolefin, process for producing the same, and thermoplastic resin composition containing branched polyolefin MITSUI CHEMICALS INC (JP) 2003-01-22 CN disclosed
EP-0790260-B1 Solid catalyst components for polymerization JAPAN POLYOLEFINS CO LTD (JP) 2002-11-06 EP disclosed
US-20010044375-A1 Olefin polymerization catalyst and process for preparing polypropylene and propylene block copolymer SHINOZAKI TETSUNORI (JP) 2001-11-22 US disclosed
US-6271166-B1 COORDINATION CATALYSTS MITSUI CHEMICALS INC (JP) 2001-08-07 US disclosed
US-6214939-B1 OLEFIN POLYMERIZATION CATALYST IS A CONTACT PRODUCT OF (A) A SOLID TITANIUM COMPONENT COMPRISING MAGNESIUM, TITANIUM, HALOGEN AND ELECTRON DONAR,(B) ORGANOMETALLIC COMPOUND,(C) AN ORGANOSILICON COMPOUND AND A COMPOUND WITH TWO ETHER LINKAGES MITSUI CHEMICALS (JP) 2001-04-10 US disclosed
CN-1063763-C Olefin polymer composition MITSUI PETROCHEMICAL INC (JP) 2001-03-28 CN disclosed
EP-0743326-B1 Solid titanium catalyst component, process for preparing same, olefin polymerization catalyst containing same, and olefin polymerization process MITSUI CHEMICALS INC (JP) 1999-08-18 EP disclosed
US-5902765-A MADE BY REACTING A MAGNESIUM DIHALIDE WITH TETRAHYDROFURAN, BUTYL ETHER OR DIETHYL ETHER AND TREATING THE SOLID SUBSTANCE WITH AN ELECTRON DONATIVE COMPOUND HAVING TWO OR MORE ALKOXY OR ESTER GROUPS, CONTACTING WITH TITANIUM; STEREOREGULARITY JAPAN POLYOLEFINS CO., LTD. (JP) 1999-05-11 US disclosed
EP-0854156-A2 Olefin polymerization catalyst and process for preparing polypropylene and propylene block copolymer MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) 1998-07-22 EP disclosed
EP-0790260-A1 Solid catalyst components for polymerization JAPAN POLYOLEFINS CO., LTD. (JP) 1997-08-20 EP disclosed
EP-0743326-A1 Solid titanium catalyst component, process for preparing same, olefin polymerization catalyst containing same, and olefin polymerization process MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) 1996-11-20 EP disclosed
EP-0641807-A2 Olefin polymerization catalyst and process for preparing polypropylene and a propylene block copolymer MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) 1995-03-08 EP disclosed
CN-1069279-A Olefin polymer compositions MITUSI PETROCHEMICAL INC LTD (JP) 1993-02-24 CN disclosed