Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 8/20 | 0.52 |
| ▸ | KDR | P35968 | 7/20 | 0.51 |
| ▸ | CDK2 | P24941 | 3/20 | 0.51 |
| ▸ | SYK | P43405 | 4/20 | 0.47 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.47 |
| ▸ | FCER2 | P06734 | 2/20 | 0.47 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.47 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 5/20 | 0.45 |
| ▸ | LCK | P06239 | 5/20 | 0.45 |
| ▸ | FYN | P06241 | 5/20 | 0.45 |
| ▸ | YES1 | P07947 | 5/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | CSF1R | P07333 | 1/20 | 0.44 |
| ▸ | KIT | P10721 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5370088 | 0.83 | SRC (0.51) | SRCKDRCDK2SYKNTRK1 | |
| SCHEMBL7132931 | 0.82 | MOGAT2 (0.52) | PDPK1BRD4 | |
| SCHEMBL5362175 | 0.82 | GSK3B (0.61) | SRCKDRCDK2SYKNTRK1 | |
| SCHEMBL7139377 | 0.82 | SRC (0.51) | SRCKDRCDK2SYKNTRK1 | |
| SCHEMBL5369843 | 0.80 | SRC (0.59) | SRCKDRCDK2SYKNTRK1 | |
| SCHEMBL5376944 | 0.80 | SYK (0.52) | SRCKDRCDK2SYKNTRK1 | |
| SCHEMBL1388519 | 0.79 | RET (0.54) | PDGFRBEGFRCSF1RKITPDPK1 | |
| SCHEMBL7138968 | 0.79 | MAPT (0.49) | SRCKDRNTRK1PDGFRBFGFR1 | |
| SCHEMBL13080589 | 0.79 | LRRK2 (0.61) | PDGFRB | |
| SCHEMBL1388393 | 0.79 | PDPK1 (0.54) | KDRPDGFRBEGFRCSF1RKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6506763-B2 | Useful in prevention and treatment of protein kinase related disorders such as cancer | SUGEN, INC. | 2003-01-14 | — | — | US | disclosed |