Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 3/20 | 0.52 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.52 |
| ▸ | FCER2 | P06734 | 2/20 | 0.52 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.52 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.52 |
| ▸ | SRC | P12931 | 13/20 | 0.50 |
| ▸ | KDR | P35968 | 8/20 | 0.49 |
| ▸ | CDK2 | P24941 | 2/20 | 0.49 |
| ▸ | LCK | P06239 | 7/20 | 0.47 |
| ▸ | FYN | P06241 | 7/20 | 0.47 |
| ▸ | YES1 | P07947 | 7/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 7/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 6/20 | 0.46 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5361781 | 0.84 | MOGAT2 (0.51) | SYKNTRK1FCER2NTRK3NTRK2 | |
| SCHEMBL5365974 | 0.82 | MAPT (0.48) | SYKNTRK1FCER2NTRK3NTRK2 | |
| SCHEMBL7138017 | 0.80 | SRC (0.52) | SYKNTRK1FCER2NTRK3NTRK2 | |
| SCHEMBL5369843 | 0.78 | SRC (0.59) | SYKNTRK1FCER2NTRK3NTRK2 | |
| SCHEMBL7139377 | 0.78 | SRC (0.51) | SYKNTRK1FCER2NTRK3NTRK2 | |
| SCHEMBL5365470 | 0.78 | SMN1; SMN2 (0.45) | SYKNTRK1FCER2NTRK3NTRK2 | |
| SCHEMBL7136077 | 0.78 | SYK (0.78) | SYKNTRK1FCER2NTRK3NTRK2 | |
| SCHEMBL5370088 | 0.77 | SRC (0.51) | SYKNTRK1FCER2NTRK3NTRK2 | |
| SCHEMBL5988780 | 0.77 | ADAMTS5 (0.48) | SYKNTRK1KDRADAMTS5MEN1 | |
| SCHEMBL7137514 | 0.76 | SYK (0.52) | SYKNTRK1FCER2NTRK3NTRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7202265-B2 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | SUGEN, INC. (US) | 2007-04-10 | — | — | US | disclosed |
| US-20050197382-A1 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | SUGEN, INC. | 2005-09-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050197382-A1 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | FRK, PTK2, DSTYK | SYK 54/4885NTRK1 223/4885FCER2 1878/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.